Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Etonogestrel. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR known ✓ | P06401 | 8/20 | 1.00 |
| ▸ | SHBG | P04278 | 9/20 | 1.00 |
| ▸ | ESR1 | P03372 | 6/20 | 1.00 |
| ▸ | AR | P10275 | 6/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 3/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.72 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.72 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.72 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.72 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.72 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.72 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.72 |
| ▸ | DRD1 | P21728 | 1/20 | 0.72 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.72 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.72 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.72 |
| ▸ | CCKBR | P32239 | 1/20 | 0.72 |
| ▸ | DRD3 | P35462 | 1/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 5/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Etonogestrel SCHEMBL484265 | 1.00 | SHBG (1.00) | SHBGPGRESR1AROPRM1 | |
| Etonogestrel SCHEMBL14946854 | 1.00 | SHBG (1.00) | SHBGPGRESR1AROPRM1 | |
| Etonogestrel SCHEMBL1649327 | 1.00 | SHBG (1.00) | SHBGPGRESR1AROPRM1 | |
| Etonogestrel SCHEMBL19510085 | 1.00 | SHBG (1.00) | SHBGPGRESR1AROPRM1 | |
| Etonogestrel SCHEMBL6462179 | 1.00 | SHBG (1.00) | SHBGPGRESR1AROPRM1 | |
| Etonogestrel SCHEMBL28648883 | 0.99 | SHBG (0.98) | SHBGPGRESR1AROPRM1 | |
| Etonogestrel SCHEMBL14941286 | 0.93 | SHBG (0.87) | SHBGPGRESR1AROPRM1 | |
| SCHEMBL20851741 | 0.93 | SHBG (0.86) | SHBGPGRESR1AROPRM1 | |
| Etonogestrel SCHEMBL5729815 | 0.90 | SHBG (0.81) | SHBGPGRESR1AROPRM1 | |
| Etonogestrel SCHEMBL6150744 | 0.90 | SHBG (0.81) | SHBGPGRESR1AROPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 5811 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026099483-A1 | A READY-TO-USE DRUG DELIVERY SYSTEM | SEVER PHARMA SOLUTIONS (SE) | 2026-05-15 | — | — | WO | claimed |
| EP-3773730-B1 | DRUG DELIVERY FORMULATIONS | UNIV CALIFORNIA (US) | 2026-05-13 | — | — | EP | claimed |
| EP-4739292-A1 | A THREE-LAYERED INTRAVAGINAL RING | Sever Pharma Solutions (SE) | 2026-05-13 | — | — | EP | claimed |
| US-12616781-B2 | Tubular nonwoven structure as active agent carrier for the atraumatic treatment of hollow organs, and a process for producing the same | BVS—Best Vascular Solutions GmbH (DE) | 2026-05-05 | — | — | US | claimed |
| EP-4440706-B1 | COMPOSITIONS FOR PROMOTING HAIR GROWTH | ESTETRA SRL (BE) | 2026-04-29 | — | — | EP | claimed |
| US-20260090995-A1 | ORODISPERSIBLE DOSAGE UNIT CONTAINING AN ESTETROL COMPONENT | ESTETRA SRL (BE) | 2026-04-02 | — | — | US | claimed |
| EP-4706636-A2 | A METHOD FOR CRYSTALLIZATION OF ACTIVE PHARMACEUTICAL INGREDIENTS | Nanoform Finland Oyj (FI) | 2026-03-11 | — | — | EP | claimed |
| US-20260053736-A1 | LONG ACTING DRUG DELIVERY DEVICE AND ITS USE IN CONTRACEPTION | BAYER OY (FI) | 2026-02-26 | — | — | US | claimed |
| EP-4688001-A1 | AN INJECTABLE DELIVERY SYSTEM FOR LONG-ACTING ADMINISTRATION OF DRUGS | Queen's University of Belfast (GB) | 2026-02-11 | — | — | EP | claimed |
| US-20260034339-A1 | SUBCUTANEOUS BIODEGRADABLE RESERVOIR DEVICE | RES TRIANGLE INST (US) | 2026-02-05 | — | — | US | claimed |
| US-5098714-A | OSMOTIC, ORAL DOSAGE FORM FOR FERTILITY CONTROL | ALZA CORPORATION (US) | 1992-03-24 | — | — | US | claimed |
| EP-0472645-A1 | OSMOTIC DOSAGE FORM. | ALZA CORP (US) | 1992-03-04 | — | — | EP | claimed |
| US-5088505-A | CONTRACEPTIVE IMPLANT | AKZO N.V. (NL) | 1992-02-18 | — | — | US | claimed |
| WO-1991007173-A1 | OSMOTIC, ORAL DOSAGE FORM FOR FERTILITY CONTROL | ALZA CORPORATION (US) | 1991-05-30 | — | — | WO | claimed |
| WO-1990014075-A1 | OSMOTIC DOSAGE FORM | ALZA CORPORATION (US) | 1990-11-29 | — | — | WO | claimed |
| US-4957119-A | ACTIVE MATERIAL IN ETHYLENE-VINYL ACETATE MATRIX | AKZO N.V. (NL) | 1990-09-18 | — | — | US | claimed |
| US-4948593-A | SUSTAINED AND CONTROLLED CONTRACEPTION | ALZA CORPORATION (US) | 1990-08-14 | — | — | US | claimed |
| EP-0303306-A1 | Contraceptive implant | AKZO N.V. (NL) | 1989-02-15 | — | — | EP | claimed |
| WO-1988000469-A1 | COMBINATION DOSAGE FORM FOR PRE-MENOPAUSAL WOMEN | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-01-28 | — | — | WO | claimed |
| EP-0253607-A1 | Combination dosage form for premenopausal women | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-01-20 | — | — | EP | claimed |