Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 11/20 | 0.67 |
| ▸ | ADRB3 | P13945 | 11/20 | 0.67 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.67 |
| ▸ | DRD2 | P14416 | 2/20 | 0.67 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.67 |
| ▸ | PGR | P06401 | 1/20 | 0.67 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.67 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | DRD3 | P35462 | 1/20 | 0.67 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11670949 | 0.89 | ADRB2 (0.62) | ADRB2ADRB3ADRB1DRD2SLC6A4 | |
| SCHEMBL11670145 | 0.87 | ADRB2 (0.60) | ADRB2ADRB3ADRB1SLC6A4ADRA1A | |
| SCHEMBL11810215 | 0.85 | ADRB2 (0.73) | ADRB2ADRB3ADRB1DRD2SLC6A4 | |
| SCHEMBL29866225 | 0.82 | ADRB2 (0.69) | ADRB2ADRB3ADRB1DRD2SLC6A4 | |
| SCHEMBL593753 | 0.82 | ADRB2 (0.69) | ADRB2ADRB3ADRB1DRD2SLC6A4 | |
| SCHEMBL27657195 | 0.82 | ADRB2 (0.69) | ADRB2ADRB3ADRB1DRD2SLC6A4 | |
| SCHEMBL15271352 | 0.82 | ADRB2 (0.69) | ADRB2ADRB3ADRB1DRD2SLC6A4 | |
| SCHEMBL721150 | 0.82 | ADRB2 (0.69) | ADRB2ADRB3ADRB1DRD2SLC6A4 | |
| SCHEMBL593754 | 0.82 | ADRB2 (0.69) | ADRB2ADRB3ADRB1DRD2SLC6A4 | |
| SCHEMBL11368373 | 0.82 | SLC6A4 (0.50) | ADRB2ADRB3ADRB1DRD2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4048229-A | ANTAGONIST ACTIVITY | SMITHKLINE CORPORATION (US) | 1977-09-13 | — | — | US | disclosed |