SCHEMBL721150

SCHEMBL721150

COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(N)c2)cc1

nearest known ligand 0.69

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ADRB2 P07550 17/20 0.69
ADRB1 P08588 5/20 0.69
ADRB3 P13945 3/20 0.69
DRD2 P14416 2/20 0.69
SLC6A4 P31645 2/20 0.69
ADRA1A P35348 2/20 0.69
PGR P06401 1/20 0.69
PTGS2 P35354 1/20 0.69
SLC6A3 Q01959 1/20 0.69
CYP1A2 P05177 1/20 0.69
CYP3A4 P08684 1/20 0.69
CYP2D6 P10635 1/20 0.69
TSHR P16473 1/20 0.69
MAPK1 P28482 1/20 0.69
CYP2C19 P33261 1/20 0.69
DRD3 P35462 1/20 0.69
HTR1A P08908 1/20 0.56
SLC6A2 P23975 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL593753 1.00 ADRB2 (0.69) ADRB2ADRB1ADRB3DRD2SLC6A4
SCHEMBL29866225 1.00 ADRB2 (0.69) ADRB2ADRB1ADRB3DRD2SLC6A4
SCHEMBL27657195 1.00 ADRB2 (0.69) ADRB2ADRB1ADRB3DRD2SLC6A4
SCHEMBL15271352 1.00 ADRB2 (0.69) ADRB2ADRB1ADRB3DRD2SLC6A4
SCHEMBL593754 1.00 ADRB2 (0.69) ADRB2ADRB1ADRB3DRD2SLC6A4
SCHEMBL11810215 0.89 ADRB2 (0.73) ADRB2ADRB1ADRB3DRD2SLC6A4
SCHEMBL4684534 0.89 ADRA1A (0.71) ADRB2ADRB1ADRB3DRD2SLC6A4
SCHEMBL594467 0.86 ADRB2 (0.70) ADRB2ADRB1ADRB3DRD2SLC6A4
SCHEMBL594466 0.86 ADRB2 (0.70) ADRB2ADRB1ADRB3DRD2SLC6A4
Salmefamol SCHEMBL20285629 0.85 ADRB2 (0.67) ADRB2ADRB1ADRB3DRD2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116136523-A Separation detection method for formoterol powder fog agent content of budesonide fumarate 苏州易合医药有限公司 2023-05-19 CN claimed
US-20120053246-A1 PURIFICATION PROCESS FOR PREPARING HIGHLY PURE ARFORMOTEROL TARTRATE SUBSTANTIALLY FREE OF DESFORMYL IMPURITY ACTAVIS GROUP PTC EHF (IS) 2012-03-01 US claimed
CN-116136523-A Separation detection method for formoterol powder fog agent content of budesonide fumarate 苏州易合医药有限公司 2023-05-19 CN disclosed
CN-110376313-B Method for detecting impurities in formoterol fumarate or related preparation thereof 广州健康元呼吸药物工程技术有限公司 2022-06-07 CN disclosed
EP-2305635-B1 FORMOTEROL TARTRATE, PROCESS AND POLYMORPH SUNOVION PHARMACEUTICALS INC (US) 2018-06-13 EP disclosed
EP-2825525-B1 NEW POLYMORPHIC FORM OF A LONG-ACTING BETA-2 ADRENOCEPTOR AGONIST LESVI LABORATORIOS SL (ES) 2018-04-25 EP disclosed
US-9499475-B2 Process for the preparation of arformoterol or salt thereof GLENMARK PHARMACEUTICALS LIMITED (IN) 2016-11-22 US disclosed
US-9499475-B2 Process for the preparation of arformoterol or salt thereof GLENMARK PHARMACEUTICALS LIMITED (IN) 2016-11-22 US disclosed
CN-104220420-B Novel polycrystal of long-acting beta-2 adrenoceptor agonist 利斯维实验室有限公司 2016-08-31 CN disclosed
US-9309186-B2 Polymorphic form of a long-acting beta-2 adrenoceptor agonist LABORATORIOS LESVI S.L. (ES) 2016-04-12 US disclosed
US-20160083334-A1 PROCESS FOR THE PREPARATION OF ARFORMOTEROL OR SALT THEREOF GLENMARK LIFE SCIENCES LIMITED (IN) 2016-03-24 US disclosed
US-20090156862-A1 Formoterol Tartrate Process and Polymorph SEPRACOR INC. (US) 2009-06-18 US disclosed
US-7479572-B2 Formoterol tartrate process and polymorph SEPRACOR INC. (US) 2009-01-20 US disclosed
US-7479572-B2 Formoterol tartrate process and polymorph SEPRACOR INC. (US) 2009-01-20 US disclosed
US-20080114187-A1 FORMOTEROL TARTRATE PROCESS AND POLYMORPH SEPRACOR INC. (US) 2008-05-15 US disclosed
US-20080114187-A1 FORMOTEROL TARTRATE PROCESS AND POLYMORPH SEPRACOR INC. (US) 2008-05-15 US disclosed
US-7342132-B2 Formoterol tartrate process and polymorph SEPRACOR INC. (US) 2008-03-11 US disclosed
US-7342132-B2 Formoterol tartrate process and polymorph SEPRACOR INC. (US) 2008-03-11 US disclosed
US-6071971-A FOR TREATING PULMONARY DISORDERS SEPRACOR INC. (US) 2000-06-06 US disclosed
US-5965622-A BRONCHODILATORS; HIGHLY SELECTIVE BETA 2-ADRENERGIC RECEPTOR AGONIST; RESPIRATORY DISORDERS, E.G. ASTHMA, BRONCHITIS; REDUCTION OF A PROTECTED NITRO DERIVATIVE; STEREOSPECIFIC SEPRACOR INC. (US) 1999-10-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090156862-A1 Formoterol Tartrate Process and Polymorph ADRB1, ADRA1B, ADRA1A ADRB2 5/4885ADRB1 1/4885ADRB3 7/4885
US-20080114187-A1 FORMOTEROL TARTRATE PROCESS AND POLYMORPH ADRB1, ADRA1B, ADRA1A ADRB2 5/4885ADRB1 1/4885ADRB3 7/4885
US-20120053246-A1 PURIFICATION PROCESS FOR PREPARING HIGHLY PURE ARFORMOTEROL TARTRATE SUBSTANTIALLY FREE OF DESFORMYL IMPURITY ADRB1, ADRB2, ADRA1A ADRB2 2/4885ADRB1 1/4885ADRB3 5/4885
US-20160083334-A1 PROCESS FOR THE PREPARATION OF ARFORMOTEROL OR SALT THEREOF AGT, AGTR1, REN ADRB2 8/4885ADRB1 5/4885ADRB3 14/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.