Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPM1B | O75688 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19816460 | 0.79 | PPM1B (0.41) | PPM1BPTPN1PPP1CCPDK1ALDH1A1 | |
| SCHEMBL19816450 | 0.79 | PPM1B (0.41) | PPM1BPTPN1PPP1CCPDK1ALDH1A1 | |
| SCHEMBL11791130 | 0.78 | BRD4 (0.40) | ALDH1A1KMT2ATSHRHTTSMN1; SMN2 | |
| SCHEMBL23753960 | 0.78 | ALDH1A1 (0.41) | ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL17111609 | 0.78 | PDK1 (0.41) | PPM1BPTPN1PPP1CCPDK1ALDH1A1 | |
| SCHEMBL2533989 | 0.77 | MAPT (0.46) | PDK1ALDH1A1KMT2ATSHR | |
| SCHEMBL18845124 | 0.75 | PPM1B (0.46) | PPM1BPTPN1PPP1CCPDK1ALDH1A1 | |
| SCHEMBL526510 | 0.73 | PPM1B (0.55) | PPM1BPTPN1PPP1CCALDH1A1SMN1; SMN2 | |
| SCHEMBL6141464 | 0.73 | — | — | |
| SCHEMBL19409680 | 0.73 | ALDH1A1 (0.43) | PDK1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3931288-A | ANTIINFLAMMATORY, ANTIRHEUMATIC | HOFFMANN-LA ROCHE INC. (US) | 1976-01-06 | — | — | US | disclosed |