Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mefenamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 5/20 | 0.56 |
| ▸ | PTGS1 known ✓ | P23219 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.56 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.56 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.56 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | DHFR | P00374 | 1/20 | 0.56 |
| ▸ | MPO | P05164 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.56 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mefenamic Acid SCHEMBL9928882 | 0.87 | PTGS2 (0.71) | PTGS2LMNACYP1A2CYP2C9PTGS1 | |
| Mefenamic Acid SCHEMBL10503020 | 0.84 | PTGS2 (0.71) | PTGS2LMNACYP1A2CYP2C9PTGS1 | |
| Mefenamic Acid SCHEMBL16179953 | 0.84 | PTGS2 (0.71) | PTGS2LMNACYP1A2CYP2C9PTGS1 | |
| Mefenamic Acid SCHEMBL11788882 | 0.80 | PTGS2 (0.58) | PTGS2LMNACYP1A2CYP2C9PTGS1 | |
| Aspirin SCHEMBL21328428 | 0.80 | KDM4E (0.67) | PTGS2LMNACYP1A2CYP2C9PTGS1 | |
| Aspirin SCHEMBL219950 | 0.80 | KDM4E (0.67) | PTGS2LMNACYP1A2CYP2C9PTGS1 | |
| SCHEMBL2700124 | 0.78 | NPC1 (0.63) | PTGS2LMNAPTGS1KMT2ANAPRT | |
| Aspirin SCHEMBL3677210 | 0.77 | KDM4E (0.67) | PTGS2LMNACYP1A2CYP2C9PTGS1 | |
| Aspirin SCHEMBL25284 | 0.77 | KDM4E (0.67) | PTGS2LMNACYP1A2CYP2C9PTGS1 | |
| Aspirin SCHEMBL2157062 | 0.77 | KDM4E (0.67) | PTGS2LMNACYP1A2CYP2C9PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3988333-A | Tri-substituted aluminum salts or di-substituted aluminum salts of carboxyl group-containing, pharmaceutically effective compounds | TEIKOKU HORMONE MFG. CO., LTD. (JA) | 1976-10-26 | — | — | US | disclosed |