Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mefenamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 4/20 | 0.71 |
| ▸ | PTGS1 known ✓ | P23219 | 3/20 | 0.71 |
| ▸ | LMNA | P02545 | 4/20 | 0.71 |
| ▸ | MEN1 | O00255 | 4/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.71 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.71 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.71 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.71 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.71 |
| ▸ | DHFR | P00374 | 1/20 | 0.71 |
| ▸ | MPO | P05164 | 1/20 | 0.71 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.71 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.71 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.71 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.71 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mefenamic Acid SCHEMBL10503020 | 0.97 | PTGS2 (0.71) | PTGS2LMNAMEN1KMT2ACYP1A2 | |
| Mefenamic Acid SCHEMBL9928882 | 0.97 | PTGS2 (0.71) | PTGS2LMNAMEN1KMT2ACYP1A2 | |
| Mefenamic Acid SCHEMBL11788882 | 0.86 | PTGS2 (0.58) | PTGS2LMNAMEN1KMT2ACYP1A2 | |
| Mefenamic Acid SCHEMBL27722088 | 0.86 | LMNA (0.74) | PTGS2LMNAMEN1KMT2ACYP1A2 | |
| Mefenamic Acid SCHEMBL11788892 | 0.84 | PTGS2 (0.56) | PTGS2LMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL7925344 | 0.83 | PTGS2 (0.76) | PTGS2LMNAMEN1KMT2ACYP1A2 | |
| Mefenamic Acid SCHEMBL29465887 | 0.83 | PTGS2 (1.00) | PTGS2LMNAMEN1KMT2ACYP1A2 | |
| Mefenamic Acid SCHEMBL29350572 | 0.83 | PTGS2 (1.00) | PTGS2LMNAMEN1KMT2ACYP1A2 | |
| Mefenamic Acid SCHEMBL29355128 | 0.83 | PTGS2 (1.00) | PTGS2LMNAMEN1KMT2ACYP1A2 | |
| Mefenamic Acid SCHEMBL3544 | 0.83 | PTGS2 (1.00) | PTGS2LMNAMEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9815067-B2 | Electret webs with charge-enhancing additives | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2017-11-14 | — | — | US | claimed |
| US-20160067717-A1 | ELECTRET WEBS WITH CHARGE-ENHANCING ADDITIVES | 3M INNOVATIVE PROPERTIES COMPANY | 2016-03-10 | — | — | US | claimed |
| EP-2986354-A2 | ELECTRET WEBS WITH CHARGE-ENHANCING ADDITIVES | 3M Innovative Properties Company (US) | 2016-02-24 | — | — | EP | claimed |
| WO-2014172308-A2 | ELECTRET WEBS WITH CHARGE-ENHANCING ADDITIVES | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2014-10-23 | — | — | WO | claimed |
| US-9815067-B2 | Electret webs with charge-enhancing additives | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2017-11-14 | — | — | US | disclosed |
| EP-2986354-B1 | ELECTRET WEBS WITH CHARGE-ENHANCING ADDITIVES | 3M INNOVATIVE PROPERTIES CO (US) | 2017-06-14 | — | — | EP | disclosed |
| US-20160067717-A1 | ELECTRET WEBS WITH CHARGE-ENHANCING ADDITIVES | 3M INNOVATIVE PROPERTIES COMPANY | 2016-03-10 | — | — | US | disclosed |
| EP-2986354-A2 | ELECTRET WEBS WITH CHARGE-ENHANCING ADDITIVES | 3M Innovative Properties Company (US) | 2016-02-24 | — | — | EP | disclosed |
| WO-2014172308-A2 | ELECTRET WEBS WITH CHARGE-ENHANCING ADDITIVES | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2014-10-23 | — | — | WO | disclosed |