Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.86 |
| ▸ | APP | P05067 | 3/20 | 0.67 |
| ▸ | ACMSD | Q8TDX5 | 3/20 | 0.64 |
| ▸ | HNF4A | P41235 | 2/20 | 0.64 |
| ▸ | DHFR | P00374 | 1/20 | 0.64 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.64 |
| ▸ | GSTA1 | P08263 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL928289 | 0.93 | ALOX5 (1.00) | ALOX5APPACMSDHNF4ADHFR | |
| SCHEMBL29848221 | 0.93 | ALOX5 (1.00) | ALOX5APPACMSDHNF4ADHFR | |
| Formaldehyde SCHEMBL28374238 | 0.91 | ALOX5 (0.86) | ALOX5APPACMSDHNF4ADHFR | |
| SCHEMBL27714322 | 0.91 | ALOX5 (0.95) | ALOX5APPACMSDHNF4ADHFR | |
| Methane SCHEMBL28271157 | 0.91 | ALOX5 (0.95) | ALOX5APPACMSDHNF4ADHFR | |
| Sulfur Dioxide SCHEMBL22500872 | 0.89 | ALOX5 (0.83) | ALOX5APPACMSDHNF4ADHFR | |
| SCHEMBL28134269 | 0.88 | ALOX5 (0.91) | ALOX5APPACMSDHNF4ADHFR | |
| SCHEMBL30016853 | 0.85 | APP (0.90) | ALOX5APPKDM4EMEN1USP2 | |
| SCHEMBL27880220 | 0.84 | ALOX5 (0.83) | ALOX5APPACMSDHNF4ADHFR | |
| SCHEMBL28053825 | 0.84 | ALOX5 (0.83) | ALOX5APPACMSDHNF4ADHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3970459-A | Process for developing a direct reversal silver halide photographic light-sensitive material | FUJI PHOTO FILM CO., LTD. (JA) | 1976-07-20 | — | — | US | claimed |
| US-3970459-A | Process for developing a direct reversal silver halide photographic light-sensitive material | FUJI PHOTO FILM CO., LTD. (JA) | 1976-07-20 | — | — | US | disclosed |