Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Flufenamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 10/20 | 0.57 |
| ▸ | YAP1 | P46937 | 1/20 | 0.55 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.55 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.55 |
| ▸ | MPO | P05164 | 4/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Flufenamic Acid SCHEMBL11793234 | 1.00 | RXFP1 (0.57) | RXFP1YAP1TEAD4TEAD2MPO | |
| Flufenamic Acid SCHEMBL11795138 | 0.97 | RXFP1 (0.56) | RXFP1YAP1TEAD4TEAD2MPO | |
| Flufenamic Acid SCHEMBL1478282 | 0.88 | RXFP1 (0.71) | RXFP1YAP1TEAD4TEAD2MPO | |
| Flufenamic Acid SCHEMBL29438087 | 0.88 | RXFP1 (0.71) | RXFP1YAP1TEAD4TEAD2MPO | |
| Flufenamic Acid SCHEMBL9845498 | 0.85 | RXFP1 (0.71) | RXFP1YAP1TEAD4TEAD2MPO | |
| Flufenamic Acid SCHEMBL11524550 | 0.85 | RXFP1 (0.71) | RXFP1YAP1TEAD4TEAD2MPO | |
| Flufenamic Acid SCHEMBL11788728 | 0.85 | RXFP1 (0.71) | RXFP1YAP1TEAD4TEAD2MPO | |
| SCHEMBL12851592 | 0.79 | RXFP1 (0.78) | RXFP1YAP1TEAD4TEAD2MPO | |
| SCHEMBL2699662 | 0.78 | RXFP1 (0.69) | RXFP1CYP1A2CYP2C19 | |
| Flufenamic Acid SCHEMBL11794349 | 0.78 | RXFP1 (0.60) | RXFP1YAP1TEAD4TEAD2MPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3988333-A | Tri-substituted aluminum salts or di-substituted aluminum salts of carboxyl group-containing, pharmaceutically effective compounds | TEIKOKU HORMONE MFG. CO., LTD. (JA) | 1976-10-26 | — | — | US | disclosed |