Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dioxane SCHEMBL5992691 | 0.90 | PIK3CD (0.37) | ALDH1A1PIK3CDTSHR | |
| 3-Methylbutanol SCHEMBL5992686 | 0.85 | TSHR (0.32) | TSHR | |
| Tetrahydrofuran SCHEMBL10609672 | 0.81 | TSHR (0.53) | ALDH1A1PIK3CDTSHR | |
| Tetrahydrofuran SCHEMBL28738577 | 0.79 | TSHR (0.50) | ALDH1A1PIK3CDTSHR | |
| 3-Methylbutanol SCHEMBL12054 | 0.78 | — | — | |
| 3-Methylbutanol SCHEMBL8407955 | 0.78 | TSHR (0.50) | ALDH1A1CA1TSHR | |
| 3-Methylbutanol SCHEMBL901083 | 0.78 | TSHR (0.50) | ALDH1A1CA1TSHR | |
| 3-Methylbutanol SCHEMBL4323028 | 0.74 | — | — | |
| 3-Methylbutanol SCHEMBL3892823 | 0.74 | — | — | |
| 3-Methylbutanol SCHEMBL18229919 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111247153-B | Solid forms of 3- (5-fluorobenzofuran-3-yl) -4- (5-methyl-5H- [1,3] dioxolo [4,5-f ] indol-7-yl) pyrrole-2,5-dione | 开动疗法公司 | 2024-04-02 | — | — | CN | disclosed |
| EP-3665176-B1 | SOLID FORMS OF 3-(5-FLUOROBENZOFURAN-3-YL)-4-(5-METHYL-5H[1,3]DIOXOLO[4,5-F]INDOL-7-YL)PYRROLE-2,5-DIONE | ACTUATE THERAPEUTICS INC (US) | 2024-01-24 | — | — | EP | disclosed |
| CN-117362305-A | Solid forms of 9-ING-41 | 开动疗法公司 | 2024-01-09 | — | — | CN | disclosed |
| US-20220009939-A1 | Solid Forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione | ACTUATE THERAPEUTICS INC (US) | 2022-01-13 | — | — | US | disclosed |
| US-11136334-B2 | Solid forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione | ACTUATE THERAPEUTICS INC. (US) | 2021-10-05 | — | — | US | disclosed |
| US-20200223861-A1 | Solid Forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione | PHARMARON, INC. | 2020-07-16 | — | — | US | disclosed |
| EP-3665176-A1 | SOLID FORMS OF 3-(5-FLUOROBENZOFURAN-3-YL)-4-(5-METHYL-5H[1,3]DIOXOLO[4,5-F]INDOL-7-YL)PYRROLE-2,5-DIONE | Actuate Therapeutics Inc. (US) | 2020-06-17 | — | — | EP | disclosed |
| CN-111247153-A | Solid forms of 3- (5-fluorobenzofuran-3-yl) -4- (5-methyl-5H- [1, 3] dioxolo [4, 5-f ] indol-7-yl) pyrrole-2, 5-dione | 开动疗法公司 | 2020-06-05 | — | — | CN | disclosed |
| WO-2019032958-A1 | SOLID FORMS OF 3-(5-FLUOROBENZOFURAN-3-YL)-4-(5-METHYL-5H[1,3]DIOXOLO[4,5-F]INDOL-7-YL)PYRROLE-2,5-DIONE | ACTUATE THERAPEUTICS INC. (US) | 2019-02-14 | — | — | WO | disclosed |
| US-4060615-A | ANTIHYPERTENSIVE, PHOSPHODIESTERASE INHIBITOR | MEAD JOHNSON & COMPANY (US) | 1977-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11136334-B2 | Solid forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione | DHPS, PDCD5, IPO5 | ALDH1A1 1014/4885PIK3CD 810/4885CA1 4423/4885 |
| US-20200223861-A1 | Solid Forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione | DHPS, PDCD5, IPO5 | ALDH1A1 1014/4885PIK3CD 810/4885CA1 4423/4885 |
| US-20220009939-A1 | Solid Forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione | DHPS, PDCD5, IPO5 | ALDH1A1 1014/4885PIK3CD 810/4885CA1 4423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.