Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 1/20 | 0.53 |
| ▸ | FEN1 | P39748 | 1/20 | 0.53 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | CASP1 | P29466 | 2/20 | 0.47 |
| ▸ | CASP7 | P55210 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HEXA | P06865 | 3/20 | 0.46 |
| ▸ | HEXB | P07686 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9064462 | 0.84 | TDP1 (0.49) | ALDH1A1KDM4EHPGDHSD17B10GAA | |
| SCHEMBL15485548 | 0.80 | ERCC1 (0.49) | ERCC1FEN1ERCC4ALDH1A1KDM4E | |
| SCHEMBL4438479 | 0.77 | ALDH1A1 (0.61) | ERCC1FEN1ERCC4ALDH1A1KDM4E | |
| SCHEMBL12386897 | 0.75 | CYP1B1 (0.59) | ERCC1FEN1ERCC4ALDH1A1KDM4E | |
| SCHEMBL4195640 | 0.73 | CYP1B1 (0.57) | ERCC1FEN1ERCC4ALDH1A1KDM4E | |
| SCHEMBL28150387 | 0.73 | ERCC1 (0.42) | ERCC1FEN1ERCC4ALDH1A1KDM4E | |
| SCHEMBL1506415 | 0.73 | CYP1B1 (0.49) | ERCC1FEN1ERCC4ALDH1A1KDM4E | |
| SCHEMBL2639668 | 0.73 | ERCC1 (0.57) | ERCC1FEN1ERCC4ALDH1A1KDM4E | |
| SCHEMBL10299247 | 0.73 | KDM4E (0.57) | ERCC1FEN1ERCC4ALDH1A1KDM4E | |
| SCHEMBL29279659 | 0.73 | ERCC1 (0.57) | ERCC1FEN1ERCC4ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4006238-A | Use of 2-(hydroxyalkyl)-1H-benz[de]isoquinoline-1,3(2H)-diones as anti-allergy agents | E. R. SQUIBB & SONS, INC. (US) | 1977-02-01 | — | — | US | disclosed |
| US-4006238-A | Use of 2-(hydroxyalkyl)-1H-benz[de]isoquinoline-1,3(2H)-diones as anti-allergy agents | E. R. SQUIBB & SONS, INC. (US) | 1977-02-01 | — | — | US | disclosed |