Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.64 |
| ▸ | PGR | P06401 | 5/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.64 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.64 |
| ▸ | SHBG | P04278 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.64 |
| ▸ | ESR1 | P03372 | 1/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.64 |
| ▸ | AR | P10275 | 4/20 | 0.62 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Normethandrone SCHEMBL148631 | 0.82 | PGR (0.73) | CYP19A1PGRCYP3A4ABCB11LMNA | |
| Normethandrone SCHEMBL23801610 | 0.82 | PGR (0.73) | CYP19A1PGRCYP3A4ABCB11LMNA | |
| Normethandrone SCHEMBL148632 | 0.82 | PGR (0.73) | CYP19A1PGRCYP3A4ABCB11LMNA | |
| SCHEMBL24476256 | 0.81 | CYP3A4 (0.70) | CYP19A1PGRCYP3A4ABCB11LMNA | |
| SCHEMBL13160889 | 0.80 | PGR (0.67) | CYP19A1PGRCYP3A4ABCB11LMNA | |
| SCHEMBL11942939 | 0.80 | PGR (0.67) | CYP19A1PGRCYP3A4ABCB11LMNA | |
| SCHEMBL4213469 | 0.80 | PGR (0.65) | CYP19A1PGRCYP3A4ABCB11LMNA | |
| SCHEMBL13160503 | 0.80 | PGR (0.67) | CYP19A1PGRCYP3A4ABCB11LMNA | |
| SCHEMBL8425076 | 0.79 | PGR (0.64) | CYP19A1PGRCYP3A4ABCB11LMNA | |
| Norethandrolone SCHEMBL23801611 | 0.79 | LMNA (0.71) | CYP19A1PGRCYP3A4ABCB11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3968132-A | (17R)-Spiro-[androstane-17,1'-cyclobutan]-2'-ones, methods for their manufacture and intermediates useful therein | SCHERING CORPORATION (US) | 1976-07-06 | — | — | US | disclosed |