Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | AQP1 | P29972 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11802057 | 1.00 | CA2 (0.56) | CA2LMNAALDH1A1KDM4EUSP2 | |
| SCHEMBL11803110 | 0.91 | HSD17B10 (0.55) | CA2LMNAALDH1A1KDM4EUSP2 | |
| SCHEMBL11803118 | 0.91 | HSD17B10 (0.55) | CA2LMNAALDH1A1KDM4EUSP2 | |
| Hydrochloric Acid SCHEMBL11803363 | 0.88 | HPGD (0.57) | CA2LMNAALDH1A1KDM4EUSP2 | |
| Hydrochloric Acid SCHEMBL11803371 | 0.88 | HPGD (0.57) | CA2LMNAALDH1A1KDM4EUSP2 | |
| SCHEMBL11802238 | 0.85 | KDM4E (0.78) | CA2LMNAALDH1A1KDM4EUSP2 | |
| SCHEMBL11808102 | 0.85 | CA2 (0.61) | CA2LMNAALDH1A1KDM4EUSP2 | |
| SCHEMBL11777604 | 0.83 | CA2 (0.43) | CA2LMNAALDH1A1KDM4EUSP2 | |
| SCHEMBL11777610 | 0.83 | CA2 (0.43) | CA2LMNAALDH1A1KDM4EUSP2 | |
| SCHEMBL11799181 | 0.81 | CA2 (0.38) | CA2LMNAALDH1A1KDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3992440-A | DIURETICS | CIBA-GEIGY CORPORATION (US) | 1976-11-16 | — | — | US | disclosed |
| US-3982018-A | DIURETICS | CIBA-GEIGY CORPORATION (US) | 1976-09-21 | — | — | US | disclosed |
| US-3939267-A | DIURETIC | CIBA-GEIGY CORPORATION (US) | 1976-02-17 | — | — | US | disclosed |