Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | CLPP | Q16740 | 1/20 | 0.50 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11802928 | 0.84 | TSHR (0.59) | CYP3A4SMN1; SMN2HIF1ACYP2D6DRD2 | |
| SCHEMBL11804290 | 0.82 | TSHR (0.47) | CYP3A4SMN1; SMN2HIF1ATSHRMEN1 | |
| SCHEMBL11806199 | 0.80 | TSHR (0.69) | CLPPTSHRMEN1KMT2AMAPT | |
| SCHEMBL17147697 | 0.79 | CYP3A4 (0.52) | CYP3A4SMN1; SMN2HIF1ACYP2D6DRD2 | |
| SCHEMBL11803813 | 0.79 | TSHR (0.56) | TSHRKMT2AMAPTCA1LMNA | |
| SCHEMBL11800225 | 0.79 | CYP1A2 (0.56) | CLPPGPR132TSHRKMT2AP2RX7 | |
| SCHEMBL11849441 | 0.78 | TSHR (0.58) | CYP3A4SMN1; SMN2HIF1ACYP2D6DRD2 | |
| SCHEMBL11806517 | 0.77 | TSHR (0.43) | CYP3A4SMN1; SMN2HIF1ATSHRMAPT | |
| SCHEMBL11807924 | 0.77 | TSHR (0.43) | CYP3A4SMN1; SMN2HIF1ATSHRMAPT | |
| SCHEMBL11809473 | 0.77 | TSHR (0.45) | DRD2TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3975386-A | PYRIDOPYRIMIDINE-ONE INTERMEDIATES | SANDOZ, INC. (US) | 1976-08-17 | — | — | US | disclosed |