Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 7/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CLPP | Q16740 | 2/20 | 0.44 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11802928 | 0.84 | TSHR (0.59) | BRD4TSHRCLPPGPR132SMN1; SMN2 | |
| SCHEMBL11800081 | 0.82 | TSHR (0.53) | KCNN4TSHRCLPPGPR132GAA | |
| SCHEMBL11800225 | 0.81 | CYP1A2 (0.56) | TSHRCLPPGPR132ATMKDM4E | |
| SCHEMBL11806199 | 0.80 | TSHR (0.69) | BRD4TSHRCLPPGAACA1 | |
| SCHEMBL11803813 | 0.79 | TSHR (0.56) | KCNN4TSHRALDH1A1GAACA1 | |
| SCHEMBL11800639 | 0.78 | RXFP1 (0.48) | TSHRALDH1A1 | |
| SCHEMBL11804290 | 0.76 | TSHR (0.47) | BRD4TSHRATMSMN1; SMN2KDM4E | |
| SCHEMBL11802291 | 0.74 | CYP3A4 (0.53) | TSHRCLPPGPR132CA9CA12 | |
| SCHEMBL11803846 | 0.73 | TSHR (0.45) | TSHRCLPPSMN1; SMN2ALDH1A1GAA | |
| SCHEMBL11809473 | 0.73 | TSHR (0.45) | BRD4TSHRKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3975386-A | PYRIDOPYRIMIDINE-ONE INTERMEDIATES | SANDOZ, INC. (US) | 1976-08-17 | — | — | US | disclosed |