Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083776 | 0.91 | ALDH1A1 (0.54) | NR1H4ALDH1A1HPGDCYP1A2CYP3A4 | |
| SCHEMBL1179680 | 0.87 | ALDH1A1 (0.54) | NR1H4ALDH1A1HPGDCYP1A2CYP3A4 | |
| SCHEMBL1179446 | 0.85 | ALDH1A1 (0.56) | NR1H4ALDH1A1HPGDCYP1A2CYP2D6 | |
| SCHEMBL30107672 | 0.85 | NPC1 (0.67) | ALDH1A1HPGDCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL28651978 | 0.85 | NPC1 (0.67) | ALDH1A1HPGDCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4148074 | 0.83 | CYP11B1 (0.61) | NR1H4ALDH1A1HPGDCYP1A2CYP3A4 | |
| SCHEMBL4716148 | 0.76 | BDKRB1 (0.57) | NR1H4ALDH1A1HPGDCYP1A2CYP3A4 | |
| SCHEMBL30725837 | 0.75 | ESR1 (0.72) | ALDH1A1MEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL29172477 | 0.75 | ESR1 (0.72) | ALDH1A1MEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL4255714 | 0.75 | NPC1 (0.46) | CYP3A4CYP2D6CYP2C19MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110034507-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2011-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034507-A1 | FARNESOID X RECEPTOR AGONISTS | NR1H4, NR1H3, NR1H2 | NR1H4 1/4885ALDH1A1 2656/4885HPGD 2171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.