SCHEMBL11809459

SCHEMBL11809459

O=C(O)C#Cc1ccc2ccccc2c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 7/20 0.47
ACACB O00763 1/20 0.44
CES2 O00748 1/20 0.44
CES1 P23141 1/20 0.44
ASIC3 Q9UHC3 2/20 0.44
PTPN1 P18031 1/20 0.42
MAPT P10636 2/20 0.41
PTPN7 P35236 1/20 0.41
CYP1A1 P04798 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP1B1 Q16678 1/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
F2 P00734 1/20 0.40
PLG P00747 1/20 0.40
PLAU P00749 1/20 0.40
KLKB1 P03952 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Propionic Acid SCHEMBL7821153 0.90 ACACB (0.45) FFAR1ACACBASIC3PTPN1PTPN7
SCHEMBL11807154 0.86 CYP1B1 (0.60) MAPTCYP1A1CYP1A2CYP1B1MEN1
SCHEMBL11814749 0.79 KDM4E (0.53) FFAR1MAPTCYP1A2MEN1KMT2A
SCHEMBL5573799 0.79 ASIC3 (0.53) ACACBCES2CES1ASIC3CYP1A1
SCHEMBL30447338 0.77 ASIC3 (0.63) FFAR1ACACBASIC3MAPTCYP1A1
SCHEMBL10705668 0.77 ASIC3 (0.63) FFAR1ACACBASIC3MAPTCYP1A1
SCHEMBL11809136 0.77 FFAR1 (0.43) FFAR1MAPTNPC1RAB9A
SCHEMBL11809121 0.77 FFAR1 (0.43) FFAR1MAPTMEN1KMT2ANPC1
Benzene SCHEMBL28174766 0.77 NPSR1 (0.59) FFAR1MAPTMEN1KMT2ANPC1
SCHEMBL68968 0.77 NPSR1 (0.59) FFAR1MAPTMEN1KMT2ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113429285-B Method for synthesizing hydroxyacetone ester compounds based on methylene aziridine 潍坊科技学院 2021-12-07 CN claimed
CN-113429285-A Method for synthesizing hydroxyacetone ester compounds based on methylene aziridine 潍坊科技学院 2021-09-24 CN claimed
CN-113354552-B Synthetic method of V-type organic ligand, synthetic V-type organic ligand and application thereof 合肥工业大学 2023-04-11 CN disclosed
CN-113429285-B Method for synthesizing hydroxyacetone ester compounds based on methylene aziridine 潍坊科技学院 2021-12-07 CN disclosed
CN-113429285-A Method for synthesizing hydroxyacetone ester compounds based on methylene aziridine 潍坊科技学院 2021-09-24 CN disclosed
CN-113354552-A Synthetic method of V-type organic ligand, synthesized V-type organic ligand and application thereof 合肥工业大学 2021-09-07 CN disclosed
WO-2020242046-A1 FLUOROALKENE COMPOUND PRECURSOR, METHOD FOR SYNTHESIZING PRECURSOR, AND METHOD FOR PREPARING FLUOROALKENE COMPOUND BY USING PRECURSOR 전남대학교산학협력단 2020-12-03 WO disclosed
US-3987116-A ETHYNYLARYL COMPOUNDS AND DERIVATIVES THEREOF WILLIAM H. RORER, INC. (US) 1976-10-19 US disclosed