Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pseudoephedrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | HBB | P68871 | 1/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.96 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.96 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.96 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.96 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.96 |
| ▸ | RGS12 | O14924 | 1/20 | 0.96 |
| ▸ | GLA | P06280 | 1/20 | 0.96 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.96 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.96 |
| ▸ | PKM | P14618 | 1/20 | 0.96 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.96 |
| ▸ | TSHR | P16473 | 1/20 | 0.96 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.96 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.96 |
| ▸ | HTR2A | P28223 | 1/20 | 0.96 |
| ▸ | THPO | P40225 | 1/20 | 0.96 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pseudoephedrine SCHEMBL33285 | 1.00 | KMT2A (1.00) | KMT2AMEN1HBBADRA2CCYP2D6 | |
| Racephedrine SCHEMBL321655 | 1.00 | KMT2A (1.00) | KMT2AMEN1HBBADRA2CCYP2D6 | |
| Ephedrine SCHEMBL22822 | 1.00 | KMT2A (1.00) | KMT2AMEN1HBBADRA2CCYP2D6 | |
| Racephedrine SCHEMBL28253267 | 1.00 | KMT2A (1.00) | KMT2AMEN1HBBADRA2CCYP2D6 | |
| Racephedrine SCHEMBL22824 | 1.00 | KMT2A (1.00) | KMT2AMEN1HBBADRA2CCYP2D6 | |
| Racephedrine SCHEMBL22823 | 1.00 | KMT2A (1.00) | KMT2AMEN1HBBADRA2CCYP2D6 | |
| Racephedrine SCHEMBL27878452 | 0.98 | KMT2A (0.96) | KMT2AMEN1HBBADRA2CCYP2D6 | |
| Racephedrine SCHEMBL9413942 | 0.98 | KMT2A (0.96) | KMT2AMEN1HBBADRA2CCYP2D6 | |
| Pseudoephedrine SCHEMBL17004001 | 0.98 | KMT2A (0.96) | KMT2AMEN1HBBADRA2CCYP2D6 | |
| Racephedrine SCHEMBL8098202 | 0.98 | CYP2D6 (1.00) | KMT2AMEN1HBBADRA2CCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6924273-B2 | Chondroprotective/restorative compositions and methods of use thereof | PIERCE SCOTT W (US) | 2005-08-02 | — | — | US | claimed |
| EP-2424363-A1 | COMPOSITIONS COMPRISING AN ANTIHISTAMINE, ANTITUSSIVE AND DECONGESTANT IN EXTENDED RELEASE FORMULATIONS | Atley Pharmaceuticals, Inc. (US) | 2012-03-07 | — | — | EP | disclosed |
| EP-2424534-A2 | COMPOSITIONS COMPRISING AN ANTIHISTAMINE, ANTITUSSIVE AND DECONGESTANT IN EXTENDED RELEASE FORMULATIONS | Atley Pharmaceuticals, Inc. (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010127100-A1 | COMPOSITIONS COMPRISING AN ANTIHISTAMINE, ANTITUSSIVE AND DECONGESTANT IN EXTENTED RELEASE FORMULATIONS | Atley Pharmaceuticals, Inc. (US) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010127108-A2 | COMPOSITIONS COMPRISING AN ANTIHISTAMINE, ANTITUSSIVE AND DECONGESTANT IN EXTENDED RELEASE FORMULATIONS | Atley Pharmaceuticals, Inc. (US) | 2010-11-04 | — | — | WO | disclosed |