Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.67 |
| ▸ | MEN1 | O00255 | 8/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11819294 | 0.87 | LMNA (0.57) | KMT2AMEN1LMNAGAATSHR | |
| SCHEMBL11821929 | 0.82 | ESR1 (0.53) | KMT2AMEN1LMNAGAAESR1 | |
| SCHEMBL2121606 | 0.81 | KMT2A (1.00) | KMT2AMEN1LMNAGAAESR1 | |
| SCHEMBL5922634 | 0.81 | KMT2A (0.59) | KMT2AMEN1LMNAGAATSHR | |
| SCHEMBL11816391 | 0.80 | KMT2A (0.56) | KMT2AMEN1LMNAGAAPKM | |
| SCHEMBL3919280 | 0.80 | SMN1; SMN2 (0.70) | KMT2AMEN1LMNAGAATSHR | |
| SCHEMBL11819847 | 0.79 | ESR1 (0.53) | KMT2AMEN1LMNAESR1PKM | |
| SCHEMBL11824074 | 0.78 | MEN1 (0.74) | KMT2AMEN1LMNAALDH1A1L3MBTL1 | |
| SCHEMBL12674485 | 0.78 | SLC16A1 (0.70) | KMT2AMEN1LMNATSHRALDH1A1 | |
| SCHEMBL394260 | 0.77 | LMNA (0.69) | KMT2AMEN1LMNAGAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3954994-A | Intermediates for preparing hipolipemic agents and method of lowering the blood lipid level in mammals with said agents | PFIZER INC. (US) | 1976-05-04 | — | — | US | disclosed |