Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.42 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | BRS3 | P32247 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 4/20 | 0.37 |
| ▸ | ITGB7 | P26010 | 4/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethane SCHEMBL11827755 | 0.88 | MAOB (0.48) | MAOBHCAR2MMEBRS3ITGB1 | |
| SCHEMBL11829318 | 0.88 | MAOB (0.50) | MAOBHCAR2MMEBRS3ITGB1 | |
| SCHEMBL11826932 | 0.86 | MAOB (0.41) | MAOBHCAR2MMEBRS3ITGB1 | |
| SCHEMBL11823509 | 0.86 | MAOB (0.45) | MAOBHCAR2MMEBRS3ITGB1 | |
| SCHEMBL11834365 | 0.86 | MAOB (0.48) | MAOBHCAR2MMEBRS3ITGB1 | |
| SCHEMBL11831427 | 0.86 | MAOB (0.47) | MAOBHCAR2MMEBRS3ITGB1 | |
| SCHEMBL11830406 | 0.84 | HCAR2 (0.44) | MAOBHCAR2MMEBRS3PPARG | |
| SCHEMBL11822596 | 0.83 | MAOB (0.42) | MAOBHCAR2MMEBRS3ITGB1 | |
| SCHEMBL11828270 | 0.83 | MAOB (0.42) | MAOBHCAR2MMEBRS3ITGB1 | |
| SCHEMBL11827741 | 0.83 | HCAR2 (0.43) | MAOBHCAR2MMEBRS3ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3966801-A | ANTIINFLAMMATORY AGENTS | WILLIAM H. RORER, INC. (US) | 1976-06-29 | — | — | US | disclosed |