SCHEMBL11829664

SCHEMBL11829664

N#CCC(O)Cc1ccc(-c2ccccc2Cl)cc1

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.46
MME P08473 2/20 0.43
CYP2A6 P11509 1/20 0.42
GRIA2 P42262 1/20 0.39
GRIA4 P48058 1/20 0.39
DHODH Q02127 1/20 0.38
GRM2 Q14416 1/20 0.38
AR P10275 1/20 0.37
HCAR2 Q8TDS4 2/20 0.36
ESR1 P03372 1/20 0.36
ESR2 Q92731 1/20 0.36
REN P00797 1/20 0.35
MMP2 P08253 1/20 0.35
MMP9 P14780 1/20 0.35
PPARG P37231 2/20 0.34
PPARA Q07869 2/20 0.34
ADORA2A P29274 1/20 0.34
ADORA1 P30542 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11828723 0.81 MAOB (0.51) MAOBMMECYP2A6GRM2HCAR2
SCHEMBL28842558 0.77 MAOB (0.58) MAOBMMECYP2A6GRIA2GRIA4
SCHEMBL11828202 0.77 MAOB (0.44) MAOBMMECYP2A6GRIA2GRIA4
SCHEMBL6746625 0.77 TRPA1 (0.44) MAOBESR1ESR2
SCHEMBL11824499 0.77 MME (0.62) MAOBMMECYP2A6HCAR2MMP2
SCHEMBL11836497 0.74 GRIA2 (0.40) MAOBCYP2A6GRIA2GRIA4DHODH
SCHEMBL11832648 0.73 MAOB (0.54) MAOBMMECYP2A6GRIA2GRIA4
SCHEMBL11829764 0.73 MAOB (0.49) MAOBMMECYP2A6DHODHGRM2
SCHEMBL15293416 0.73 MAOB (0.56) MAOBMMECYP2A6GRM2REN
SCHEMBL10665717 0.71 MAOB (0.63) MAOBMMECYP2A6GRM2HCAR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-3966801-A ANTIINFLAMMATORY AGENTS WILLIAM H. RORER, INC. (US) 1976-06-29 US disclosed