Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 3/20 | 0.47 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.47 |
| ▸ | KDM4A | O75164 | 2/20 | 0.45 |
| ▸ | KDM6B | O15054 | 1/20 | 0.45 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.45 |
| ▸ | KDM3B | Q7LBC6 | 1/20 | 0.45 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.45 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.45 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | DAO | P14920 | 2/20 | 0.42 |
| ▸ | BRS3 | P32247 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17844663 | 0.91 | KDM4E (0.47) | KDM5AKDM5BKDM4AKDM6BKDM4D | |
| SCHEMBL25148777 | 0.84 | KDM4E (0.41) | KDM5AKDM5BKDM4AKDM6BKDM4D | |
| SCHEMBL25148754 | 0.81 | KDM4E (0.40) | KDM5AKDM5BKDM4AKDM6BKDM4D | |
| SCHEMBL25148778 | 0.80 | KDM4E (0.39) | KDM5AKDM5BKDM4AKDM6BKDM4D | |
| SCHEMBL25148750 | 0.80 | KDM4E (0.39) | KDM5AKDM5BKDM4AKDM6BKDM4D | |
| SCHEMBL25148783 | 0.80 | KDM4E (0.39) | KDM5AKDM5BKDM4AKDM6BKDM4D | |
| SCHEMBL15614393 | 0.77 | DAO (0.46) | KDM5AKDM5BACMSDDAOHCAR2 | |
| SCHEMBL25148772 | 0.76 | DAO (0.34) | KDM5AKDM5BKDM4AKDM6BKDM4D | |
| SCHEMBL17016660 | 0.74 | DAO (0.46) | KDM4EDAOALDH1A1HPGDHSD17B10 | |
| SCHEMBL11840491 | 0.74 | DAO (0.46) | DAOGAAKMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023062575-A1 | CYCLIC VINYL SULFONE COMPOUNDS AS WRN INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2023-04-20 | — | — | WO | disclosed |
| WO-2023062575-A1 | CYCLIC VINYL SULFONE COMPOUNDS AS WRN INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2023-04-20 | — | — | WO | disclosed |
| US-3948903-A | Substituted N-(1,2-dihydro-2-oxonicotinyl)-cephalexins and -cephaloglycins | PARKE, DAVIS & COMPANY (US) | 1976-04-06 | — | — | US | disclosed |