Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 2/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KDM6B | O15054 | 2/20 | 0.33 |
| ▸ | KDM4A | O75164 | 2/20 | 0.33 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.33 |
| ▸ | HIF1AN | Q9NWT6 | 2/20 | 0.33 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.33 |
| ▸ | KDM3B | Q7LBC6 | 2/20 | 0.33 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17844663 | 0.86 | KDM4E (0.47) | KDM4EALDH1A1GAASMN1; SMN2RXFP1 | |
| SCHEMBL25148777 | 0.82 | KDM4E (0.41) | KDM4EALDH1A1GAASMN1; SMN2RXFP1 | |
| SCHEMBL11833334 | 0.81 | KDM5A (0.47) | KDM4EALDH1A1GAASMN1; SMN2RXFP1 | |
| SCHEMBL25149082 | 0.79 | KDM4E (0.33) | KDM4EGAACYP2C9CYP3A4CYP2D6 | |
| SCHEMBL25148778 | 0.78 | KDM4E (0.39) | KDM4EALDH1A1GAASMN1; SMN2RXFP1 | |
| SCHEMBL25148783 | 0.78 | KDM4E (0.39) | KDM4EALDH1A1GAASMN1; SMN2RXFP1 | |
| SCHEMBL25148750 | 0.75 | KDM4E (0.39) | KDM4EALDH1A1GAASMN1; SMN2RXFP1 | |
| SCHEMBL25149262 | 0.74 | LMNA (0.44) | ALDH1A1GAASMN1; SMN2POLBMEN1 | |
| SCHEMBL16794594 | 0.74 | KDM5A (0.36) | KDM4EALDH1A1GAASMN1; SMN2RXFP1 | |
| SCHEMBL28372623 | 0.69 | CYP2C9 (0.42) | KDM4EALDH1A1GAASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023062575-A1 | CYCLIC VINYL SULFONE COMPOUNDS AS WRN INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2023-04-20 | — | — | WO | disclosed |