SCHEMBL11833367

SCHEMBL11833367

NC(=O)c1ccc(/C=C/c2ccc(C(N)=O)cc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 2/20 0.58
HSD17B10 Q99714 2/20 0.58
ALDH1A1 P00352 2/20 0.58
PRMT5 O14744 1/20 0.58
PRMT1 Q99873 1/20 0.58
HPGD P15428 1/20 0.58
PARP10 Q53GL7 6/20 0.55
PARP3 Q9Y6F1 1/20 0.55
PARP1 P09874 2/20 0.52
TSHR P16473 2/20 0.52
POLB P06746 1/20 0.52
CYP3A4 P08684 1/20 0.52
MAPT P10636 1/20 0.52
RECQL P46063 1/20 0.52
BLM P54132 1/20 0.52
PMP22 Q01453 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.52
PARP4 Q9UKK3 2/20 0.52
PARP15 Q460N3 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11833372 1.00 CYP2C19 (0.58) CYP2C19HSD17B10ALDH1A1PRMT5PRMT1
SCHEMBL19991845 0.91 PARP10 (0.59) CYP2C19HSD17B10ALDH1A1PRMT5PRMT1
SCHEMBL16131295 0.91 MAPT (0.62) CYP2C19HSD17B10ALDH1A1PRMT5PRMT1
SCHEMBL7187617 0.91 MAPT (0.62) CYP2C19HSD17B10ALDH1A1PRMT5PRMT1
SCHEMBL4156173 0.91 MAPT (0.62) CYP2C19HSD17B10ALDH1A1PRMT5PRMT1
SCHEMBL10439486 0.89 ESR1 (0.53) CYP2C19HSD17B10ALDH1A1PRMT5PRMT1
SCHEMBL10959192 0.86 ALDH1A1 (0.59) CYP2C19HSD17B10ALDH1A1PRMT5PRMT1
SCHEMBL12736269 0.86 PARP10 (0.48) CYP2C19HSD17B10ALDH1A1PRMT5PRMT1
SCHEMBL18780435 0.85 MAPT (0.61) CYP2C19HSD17B10ALDH1A1PRMT5PRMT1
SCHEMBL10536049 0.84 HCAR2 (0.61) CYP2C19HSD17B10ALDH1A1HPGDPARP10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107892811-B Electrical insulating material having thermal conductivity, electrical insulating coating material using the same, and electrical insulated wire 东特涂料股份有限公司 2021-08-31 CN disclosed
US-20180090240-A1 ELECTRIC INSULATING MATERIAL, ELECTRIC INSULATING COATING COMPOUND AND ELECTRIC INSULATING WIRE HAVING EXCELLENT THERMAL CONDUCTION PERFORMANCE TOTOKU TORYO CO., LTD. (JP) 2018-03-29 US disclosed
US-3935195-A FLUORESCENT DYE STERLING DRUG INC. (US) 1976-01-27 US disclosed