Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 9/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MAOB | P27338 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.56 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11834524 | 1.00 | LMNA (0.63) | LMNAALDH1A1KDM4EPKMMAPT | |
| SCHEMBL1225557 | 0.98 | LMNA (0.65) | LMNAALDH1A1KDM4EPKMMAPT | |
| SCHEMBL1225556 | 0.98 | LMNA (0.65) | LMNAALDH1A1KDM4EPKMMAPT | |
| SCHEMBL3064890 | 0.90 | MAPT (0.68) | LMNAALDH1A1KDM4EPKMMAPT | |
| SCHEMBL3064887 | 0.90 | MAPT (0.68) | LMNAALDH1A1KDM4EPKMMAPT | |
| SCHEMBL29406300 | 0.90 | MAPT (0.68) | LMNAALDH1A1KDM4EPKMMAPT | |
| SCHEMBL979673 | 0.89 | MAOB (0.63) | LMNAALDH1A1KDM4EPKMMAPT | |
| SCHEMBL5454794 | 0.89 | LMNA (0.59) | LMNAALDH1A1KDM4EPKMMAPT | |
| SCHEMBL979672 | 0.89 | MAOB (0.63) | LMNAALDH1A1KDM4EPKMMAPT | |
| SCHEMBL5454800 | 0.89 | LMNA (0.59) | LMNAALDH1A1KDM4EPKMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3931152-A | ANTITUBERCULAR | AMERICAN CYANAMID COMPANY (US) | 1976-01-06 | — | — | US | disclosed |