Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.68 |
| ▸ | MAOB | P27338 | 2/20 | 0.62 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.62 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | DPP4 | P27487 | 2/20 | 0.57 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | CTSL | P07711 | 2/20 | 0.55 |
| ▸ | CTSB | P07858 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | BACE1 | P56817 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3064887 | 1.00 | MAPT (0.68) | MAPTKMT2AMEN1HSP90AA1MAOB | |
| SCHEMBL29406300 | 1.00 | MAPT (0.68) | MAPTKMT2AMEN1HSP90AA1MAOB | |
| SCHEMBL1225556 | 0.92 | LMNA (0.65) | MAPTKMT2AMEN1HSP90AA1MAOB | |
| SCHEMBL1225557 | 0.92 | LMNA (0.65) | MAPTKMT2AMEN1HSP90AA1MAOB | |
| Bromide SCHEMBL11834524 | 0.90 | LMNA (0.63) | MAPTKMT2AMEN1HSP90AA1MAOB | |
| Bromide SCHEMBL11834530 | 0.90 | LMNA (0.63) | MAPTKMT2AMEN1HSP90AA1MAOB | |
| SCHEMBL979672 | 0.86 | MAOB (0.63) | MAPTKMT2AMEN1MAOBLMNA | |
| SCHEMBL5454794 | 0.86 | LMNA (0.59) | MAPTKMT2AMEN1HSP90AA1MAOB | |
| SCHEMBL5454800 | 0.86 | LMNA (0.59) | MAPTKMT2AMEN1HSP90AA1MAOB | |
| SCHEMBL979673 | 0.86 | MAOB (0.63) | MAPTKMT2AMEN1MAOBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114085199-B | Chalcone derivative containing sulfonyl piperazine as well as preparation method and application thereof | 贵州大学 | 2023-04-21 | — | — | CN | disclosed |
| CN-114085199-A | Chalcone derivative containing sulfonyl piperazine and preparation method and application thereof | 贵州大学 | 2022-02-25 | — | — | CN | disclosed |
| US-9512087-B2 | Hybrid molecules containing pharmacophores of fluconazole as antifungal agents and their preparation | COUNCIL FOR SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-12-06 | — | — | US | disclosed |
| EP-2721014-B1 | HYBRID MOLECULES CONTAINING PHARMACOPHORES OF FLUCONAZOLE AS ANTIFUNGAL AGENTS AND THEIR PREPARATION | FDC LTD (IN) | 2016-10-26 | — | — | EP | disclosed |
| US-8618327-B2 | Antibacterial agents and methods of use thereof | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2013-12-31 | — | — | US | disclosed |
| US-20130303579-A1 | HYBRID MOLECULES CONTAINING PHARMACOPHORES OF FLUCONAZOLE AS ANTIFUNGAL AGENTS AND THEIR PREPARATION | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2013-11-14 | — | — | US | disclosed |
| US-20120277252-A1 | Antibacterial Agents and Methods of Use Thereof | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2012-11-01 | — | — | US | disclosed |
| US-8227616-B2 | Cyanopyridine antibacterial agents and methods of use thereof | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2012-07-24 | — | — | US | disclosed |
| US-20100261763-A1 | ANTIBACTERIAL AGENTS AND METHODS OF USE THEREOF | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2010-10-14 | — | — | US | disclosed |
| US-7737164-B2 | Cyanopyridine antibacterial agents | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2010-06-15 | — | — | US | disclosed |
| WO-2008016738-A2 | ANTIBACTERIAL AGENTS AND RELATED SCREENING METHODS USING SMALL MOLECULE MACROARRAYS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2008-02-07 | — | — | WO | disclosed |
| US-20080009528-A1 | ANTIBACTERIAL AGENTS AND RELATED SCREENING METHODS USING SMALL MOLECULE MACROARRAYS | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2008-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120277252-A1 | Antibacterial Agents and Methods of Use Thereof | FDPS, ABCG2, DUT | MAPT 4708/4885KMT2A 4034/4885MEN1 3582/4885 |
| US-20080009528-A1 | ANTIBACTERIAL AGENTS AND RELATED SCREENING METHODS USING SMALL MOLECULE MACROARRAYS | PCNA, ABCG2, API5 | MAPT 4803/4885KMT2A 3806/4885MEN1 3709/4885 |
| US-20100261763-A1 | ANTIBACTERIAL AGENTS AND METHODS OF USE THEREOF | FDPS, CYP3A5, ABCG2 | MAPT 4715/4885KMT2A 3947/4885MEN1 3578/4885 |
| US-20130303579-A1 | HYBRID MOLECULES CONTAINING PHARMACOPHORES OF FLUCONAZOLE AS ANTIFUNGAL AGENTS AND THEIR PREPARATION | ERG28, CYP51A1, CYP2F1 | MAPT 4343/4885KMT2A 4562/4885MEN1 934/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.