Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11929107 | 0.87 | TDP1 (0.48) | TDP1LMNACA1CA2HTT | |
| SCHEMBL20369162 | 0.84 | LMNA (0.46) | TDP1LMNACA1CA2HTT | |
| Teclothiazide SCHEMBL309921 | 0.81 | LMNA (0.65) | TDP1LMNACA1CA2HTT | |
| SCHEMBL11842114 | 0.80 | TDP1 (0.49) | TDP1LMNACA1CA2HTT | |
| SCHEMBL17471640 | 0.78 | LMNA (0.72) | TDP1LMNACA1CA2HTT | |
| Teclothiazide SCHEMBL7621916 | 0.73 | LMNA (0.83) | TDP1LMNACA1CA2HTT | |
| SCHEMBL7410862 | 0.70 | TDP1 (0.63) | TDP1LMNACA1CA2HTT | |
| Teclothiazide SCHEMBL5324541 | 0.69 | LMNA (0.61) | TDP1LMNACA1CA2HTT | |
| SCHEMBL17471573 | 0.68 | LMNA (0.72) | TDP1LMNACA1CA2HTT | |
| Ethiazide SCHEMBL122238 | 0.68 | TDP1 (1.00) | TDP1LMNACA1CA2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3969518-A | Inhibiting xanthine oxidase with 3-haloalkyl substituted benzothiadiazine-1,1-dioxides | MERCK & CO., INC. (US) | 1976-07-13 | — | — | US | claimed |