Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11840524 | 0.92 | CYP2D6 (0.51) | HDAC1KCNH2MAPTTDP1HDAC3 | |
| SCHEMBL11847083 | 0.85 | DRD2 (0.66) | HDAC1KCNH2MAPTALDH1A1KDM4E | |
| SCHEMBL11836531 | 0.79 | HTT (0.50) | MAPTHDAC8HDAC6ALDH1A1KDM4E | |
| SCHEMBL28788491 | 0.78 | HTT (0.56) | HDAC1KCNH2MAPTALDH1A1KDM4E | |
| SCHEMBL11841997 | 0.78 | ADRA2A (0.70) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL11681786 | 0.78 | KCNH2 (0.46) | HDAC1KCNH2MAPTALDH1A1GAA | |
| SCHEMBL26508424 | 0.77 | HTR2A (0.68) | HDAC1KCNH2MAPTALDH1A1KDM4E | |
| SCHEMBL11333760 | 0.77 | DRD2 (0.69) | KCNH2MAPTALDH1A1KDM4EHTR7 | |
| SCHEMBL11679502 | 0.76 | HTT (0.54) | HDAC1KCNH2MAPTALDH1A1KDM4E | |
| SCHEMBL11841119 | 0.76 | DRD2 (0.56) | KCNH2MAPTTDP1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3997539-A | HYPOTENSIVE, TRANQUILIZER | AMERICAN HOECHST CORPORATION (US) | 1976-12-14 | — | — | US | claimed |
| US-3997539-A | HYPOTENSIVE, TRANQUILIZER | AMERICAN HOECHST CORPORATION (US) | 1976-12-14 | — | — | US | disclosed |