Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.54 |
| ▸ | CFTR | P13569 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | GLA | P06280 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11840460 | 0.90 | KMT2A (0.53) | ALDH1A1HSD17B10KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL27589476 | 0.83 | ALDH1A1 (0.49) | ALDH1A1HSD17B10KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL27613249 | 0.83 | MAPT (0.64) | ALDH1A1HSD17B10CFTRKDM4EHPGD | |
| SCHEMBL2367627 | 0.82 | ALDH1A1 (0.69) | ALDH1A1HSD17B10CFTRKDM4ENPC1 | |
| SCHEMBL27422765 | 0.80 | ALDH1A1 (0.67) | ALDH1A1HSD17B10CFTRKDM4ENPC1 | |
| SCHEMBL27559645 | 0.80 | KMT2A (0.51) | ALDH1A1HSD17B10KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL4956879 | 0.78 | NPC1 (0.69) | ALDH1A1HSD17B10KDM4ENPC1RAB9A | |
| SCHEMBL12811737 | 0.78 | KMT2A (0.71) | ALDH1A1HSD17B10KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL10743516 | 0.78 | MAPT (0.60) | ALDH1A1HSD17B10CFTRKDM4ENPC1 | |
| SCHEMBL27422766 | 0.78 | ALDH1A1 (0.58) | ALDH1A1HSD17B10CFTRKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3984556-A | Alkyl-substituted-tricyclic quinazolinones for lowering blood pressure | SANDOZ, INC. (US) | 1976-10-05 | — | — | US | disclosed |
| US-3982000-A | Alkyl-substituted-tricyclic quinazolinones as bronchodilators | SANDOZ, INC. (US) | 1976-09-21 | — | — | US | disclosed |
| US-3978059-A | BRONCHODILATOR AGENTS | SANDOZ, INC. (US) | 1976-08-31 | — | — | US | disclosed |
| US-3969506-A | BRONCHODILATOR | SANDOZ, INC. (US) | 1976-07-13 | — | — | US | disclosed |
| US-3912731-A | N-substituted anthranilic anhydrides | SANDOZ AG | 1975-10-14 | — | — | US | disclosed |
| US-3905976-A | Substituted tricyclic quinazolinones | SANDOZ AG | 1975-09-16 | — | — | US | disclosed |
| US-3887559-A | Pharmacologically active tricyclic quinazolinones | SANDOZ AG | 1975-06-03 | — | — | US | disclosed |