Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | CNOT7 | Q9UIV1 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cadaverine Tartrate SCHEMBL11840590 | 0.92 | KMT2A (0.43) | KMT2ACNOT7MEN1POLBALDH1A1 | |
| Hydrochloric Acid SCHEMBL11852085 | 0.90 | CNOT7 (0.46) | KMT2ACNOT7MEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL11855033 | 0.85 | CNOT7 (0.48) | KMT2ACNOT7MEN1RXFP1 | |
| Hydrochloric Acid SCHEMBL11852871 | 0.85 | CNOT7 (0.47) | KMT2ACNOT7MEN1RXFP1 | |
| Cadaverine Tartrate SCHEMBL11851019 | 0.84 | ADORA2B (0.43) | SMN1; SMN2RXFP1 | |
| SCHEMBL11843030 | 0.82 | CNOT7 (0.44) | KMT2ACNOT7MEN1POLBALDH1A1 | |
| Hydrochloric Acid SCHEMBL11851840 | 0.81 | CNOT7 (0.48) | KMT2ACNOT7MEN1RXFP1 | |
| Hydrochloric Acid SCHEMBL11846176 | 0.80 | CNOT7 (0.47) | KMT2ACNOT7MEN1RXFP1 | |
| Hydrochloric Acid SCHEMBL11847930 | 0.78 | RXFP1 (0.64) | POLBALDH1A1SMN1; SMN2KDM4ERXFP1 | |
| Cadaverine Tartrate SCHEMBL11841907 | 0.77 | ADORA2B (0.40) | KMT2AMEN1POLBSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3998953-A | 1,3,7-Trisubstitued xanthine peripheral vasodilators | BOEHRINGER INGELHEIM GMBH (DT) | 1976-12-21 | — | — | US | disclosed |