Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 3/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.44 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9779992 | 0.86 | KEAP1 (0.56) | KEAP1NFE2L2CA1CA2PARP10 | |
| SCHEMBL11558445 | 0.81 | MAPT (0.49) | KEAP1NFE2L2CA1CA2MTNR1A | |
| SCHEMBL9771242 | 0.79 | ALDH1A1 (0.47) | CA2MAPTNPC1TP53RAB9A | |
| SCHEMBL11318899 | 0.79 | KEAP1 (0.41) | KEAP1NFE2L2RAB9ASMN1; SMN2CES2 | |
| SCHEMBL12656352 | 0.79 | CA1 (0.48) | KEAP1NFE2L2CA1CA2PARP10 | |
| SCHEMBL15132701 | 0.78 | ALDH1A1 (0.40) | MAPTNPC1RAB9AALDH1A1HTT | |
| SCHEMBL8781767 | 0.77 | ALDH1A1 (0.44) | MTNR1AMTNR1BNPC1TP53RAB9A | |
| SCHEMBL28904603 | 0.76 | CA1 (0.48) | CA1CA2PARP10PARP1PARP2 | |
| SCHEMBL2775693 | 0.75 | AOC3 (0.52) | CA1CA2MAPTSMN1; SMN2PDK2 | |
| SCHEMBL16171362 | 0.73 | SMN1; SMN2 (0.45) | KEAP1NFE2L2MTNR1AMTNR1BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3964894-A | 1-(FURYL OR THIAZOLYL)CARBONYL-2-METHYL-5-METHOXY-INDOL-3-YL ACETIC ACID | CHINOIN GYOGYSZER-ES VEGYESZETI TERMEKEK GYARA RT (HU) | 1976-06-22 | — | — | US | disclosed |