Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.38 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11856057 | 0.91 | KCNJ5 (0.41) | KCNJ5KCNJ3 | |
| SCHEMBL11852158 | 0.89 | IDO1 (0.44) | LMNATP53HTTIDO1HDAC8 | |
| SCHEMBL11853825 | 0.88 | HDAC8 (0.42) | PPARGIDO1HDAC8HDAC3HDAC1 | |
| SCHEMBL11857140 | 0.87 | PPARG (0.42) | PPARGPPARA | |
| SCHEMBL11852026 | 0.85 | IDO1 (0.41) | PPARGPPARALMNAHTTIDO1 | |
| SCHEMBL11852010 | 0.83 | PPARA (0.47) | PPARALMNATP53HTTIDO1 | |
| SCHEMBL11855715 | 0.83 | LMNA (0.40) | LMNATP53HTTIDO1 | |
| SCHEMBL8395600 | 0.81 | TP53 (0.50) | LMNATP53HTT | |
| SCHEMBL11861972 | 0.80 | CYP1A2 (0.48) | HDAC8 | |
| SCHEMBL11856524 | 0.79 | CYP1A2 (0.46) | LMNATP53HDAC8HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3991201-A | 1-(β-Aryl-β-R-ethyl)imidazoles as antimicrobial agents | JANSSEN PHARMACEUTICA N.V. (BE) | 1976-11-09 | — | — | US | disclosed |