SCHEMBL118591

SCHEMBL118591

COc1cccc(/C=C/c2cccc(OC)c2OC)c1OC

nearest known ligand 0.79

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
NFE2L2 Q16236 8/20 0.79
CYP1A1 P04798 4/20 0.71
CYP1A2 P05177 4/20 0.71
CYP1B1 Q16678 3/20 0.71
CYP19A1 P11511 1/20 0.71
KDM4E B2RXH2 1/20 0.69
MAPT P10636 1/20 0.69
HSD17B10 Q99714 1/20 0.69
PRMT1 Q99873 1/20 0.66
MEN1 O00255 1/20 0.56
NPC1 O15118 1/20 0.56
AGTR1 P30556 1/20 0.56
RAB9A P51151 1/20 0.56
KMT2A Q03164 1/20 0.56
CYP2D6 P10635 1/20 0.55
ALOX5 P09917 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL615385 0.94 NFE2L2 (0.77) NFE2L2CYP1A1CYP1A2CYP1B1CYP19A1
SCHEMBL5182341 0.92 NFE2L2 (0.69) NFE2L2CYP1A1CYP1A2CYP1B1CYP19A1
SCHEMBL21798669 0.90 NFE2L2 (0.66) NFE2L2CYP1A1CYP1A2CYP1B1CYP19A1
SCHEMBL14518616 0.90 NFE2L2 (0.66) NFE2L2CYP1A1CYP1A2CYP1B1CYP19A1
SCHEMBL7870072 0.90 NFE2L2 (0.66) NFE2L2CYP1A1CYP1A2CYP1B1CYP19A1
SCHEMBL1603723 0.89 NFE2L2 (1.00) NFE2L2CYP1A1CYP1A2CYP1B1CYP19A1
SCHEMBL5500710 0.89 NFE2L2 (1.00) NFE2L2CYP1A1CYP1A2CYP1B1CYP19A1
SCHEMBL1045608 0.88 NFE2L2 (0.64) NFE2L2CYP1A1CYP1A2CYP1B1CYP19A1
SCHEMBL5205155 0.88 NFE2L2 (0.64) NFE2L2CYP1A1CYP1A2CYP1B1CYP19A1
SCHEMBL1045609 0.88 NFE2L2 (0.64) NFE2L2CYP1A1CYP1A2CYP1B1CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 207 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230141224-A1 FIBROBLAST MEDIATED EXPANSION AND AUGMENTATION OF IMMUNE REGULATORY CELLS FOR TREATMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) FIGENE, LLC 2023-05-11 US claimed
EP-4142751-A1 FIBROBLAST MEDIATED EXPANSION AND AUGMENTATION OF IMMUNE REGULATORY CELLS FOR TREATMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) Figene, LLC (US) 2023-03-08 EP claimed
WO-2021202032-A1 FIBROBLAST MEDIATED EXPANSION AND AUGMENTATION OF IMMUNE REGULATORY CELLS FOR TREATMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) FIGENE, LLC (US) 2021-10-07 WO claimed
WO-2018210880-A1 STILBENES FOR PRE-HARVEST TREATMENT AND CROP PROTECTION EVOLVA SA (CH) 2018-11-22 WO claimed
WO-2018210872-A1 STILBENES FOR POST-HARVEST TREATMENT AND FOOD PRESERVATION AND/OR SHELF LIFE EXTENSION EVOLVA SA (CH) 2018-11-22 WO claimed
US-20160215306-A1 METHOD FOR PRODUCING MODIFIED RESVERATROL EVOLVA SA (CH) 2016-07-28 US claimed
EP-3039132-A2 A METHOD FOR PRODUCING MODIFIED RESVERATROL Evolva SA (CH) 2016-07-06 EP claimed
WO-2015028324-A2 A METHOD FOR PRODUCING MODIFIED RESVERATROL EVOLVA SA (CH) 2015-03-05 WO claimed
EP-2060255-A2 Methods and compositions for prevention and treatment of inflammatory disease, autoimmune disease, and transplant rejection The Regents Of The University Of California (US) 2009-05-20 EP claimed
EP-1450819-A4 METHODS AND COMPOSITIONS FOR PREVENTION AND TREATMENT OF INFLAMMATORY DISEASE, AUTOIMMUNE DISEASE, AND TRANSPLANT REJECTION UNIV CALIFORNIA (US) 2008-01-23 EP claimed
US-20040242500-A1 Methods and compositions for prevention and treatment of inflammatory disease, autoimmune disease, and transplant rejection THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2004-12-02 US claimed
EP-1450819-A1 METHODS AND COMPOSITIONS FOR PREVENTION AND TREATMENT OF INFLAMMATORY DISEASE, AUTOIMMUNE DISEASE, AND TRANSPLANT REJECTION The Regents of the University of California (US) 2004-09-01 EP claimed
WO-2003039557-A1 METHODS AND COMPOSITIONS FOR PREVENTION AND TREATMENT OF INFLAMMATORY DISEASE, AUTOIMMUNE DISEASE, AND TRANSPLANT REJECTION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2003-05-15 WO claimed
WO-2026102249-A1 TNF RECEPTOR SUPERFAMILY AGONIST FUSION POLYPEPTIDES ANKYRA THERAPEUTICS, INC. (US) 2026-05-15 WO disclosed
US-12606872-B2 Methods for stratification and early detection of advanced adenoma and/or colorectal cancer using DNA methylation markers Universal Diagnostics, S.A. (ES) 2026-04-21 US disclosed
EP-4691558-A2 TREATMENT OR PROPHYLAXIS OF PROLIFERATIVE CONDITIONS University Court of The University of Dundee (GB) 2026-02-11 EP disclosed
WO-2003039557-A1 METHODS AND COMPOSITIONS FOR PREVENTION AND TREATMENT OF INFLAMMATORY DISEASE, AUTOIMMUNE DISEASE, AND TRANSPLANT REJECTION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2003-05-15 WO disclosed
US-6552213-B1 Oxidation and halogenation of such as 3,4',5-tribenzyloxy-dibenzylsulfide; reductive dehalogenation desulfonation; hydrolysis ORCHID CHEMICALS & PHARMACEUTICALS LIMITED, INDIA (IN) 2003-04-22 US disclosed
US-5272270-A Process for the preparation of 1-alkylisoquinoline derivatives CONSORTIUM FUR ELEKTROCHEMISCHE INDUSTRIE GMBH (DE) 1993-12-21 US disclosed
EP-0471303-A1 Process for the preparation of 1-alkylisoquinoline derivatives Consortium für elektrochemische Industrie GmbH (DE) 1992-02-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040242500-A1 Methods and compositions for prevention and treatment of inflammatory disease, autoimmune disease, and transplant rejection TNF, HLA-DRB1, IL5 NFE2L2 730/4885CYP1A1 1344/4885CYP1A2 1036/4885
US-12606872-B2 Methods for stratification and early detection of advanced adenoma and/or colorectal cancer using DNA methylation markers DNMT3L, DNMT3A, UNG NFE2L2 2415/4885CYP1A1 1642/4885CYP1A2 2345/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.