Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | FAAH | O00519 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13981948 | 0.84 | LMNA (0.67) | MEN1KMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL10076573 | 0.81 | MC4R (0.65) | LMNAALDH1A1KDM4EHTTMAPT | |
| SCHEMBL2262681 | 0.81 | ALDH1A1 (0.57) | MEN1KMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL12981 | 0.81 | HRH3 (0.69) | ALDH1A1KDM4EHTTMAPT | |
| SCHEMBL31546411 | 0.81 | HRH3 (0.69) | ALDH1A1KDM4EHTTMAPT | |
| SCHEMBL18423019 | 0.81 | LMNA (0.62) | MEN1KMT2ALMNAFAAHCHRM2 | |
| SCHEMBL18946202 | 0.81 | LMNA (0.62) | MEN1KMT2ALMNAFAAH | |
| SCHEMBL2634372 | 0.81 | SMN1; SMN2 (0.66) | MEN1KMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL13981946 | 0.80 | LMNA (0.58) | MEN1KMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL12449574 | 0.80 | LMNA (0.74) | MEN1KMT2ALMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3642209-B1 | COMPOUNDS THAT INTERACT WITH THE RAS SUPERFAMILY FOR THE TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE | SHY Therapeutics LLC (US) | 2023-11-29 | — | — | EP | disclosed |
| WO-2017093544-A1 | ALKYNYL PHOSPHINE GOLD COMPLEXES FOR TREATING BACTERIAL INFECTIONS | AUSPHERIX LIMITED (GB) | 2017-06-08 | — | — | WO | disclosed |
| EP-2499146-B1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2016-09-21 | — | — | EP | disclosed |
| WO-2011058149-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-05-19 | — | — | WO | disclosed |