Lodoxamide

SCHEMBL11864397

N#Cc1cc(NC(=O)C(=O)O)c(Cl)c(NC(=O)C(=O)O)c1.OCC(CO)(CO)NC(CO)(CO)CO.OCC(CO)(CO)NC(CO)(CO)CO

nearest known ligand 0.78

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	GPR35	Q9HC97	13/20	0.78

▸	PDK1	Q15118	1/20	0.34

▸	PDK2	Q15119	1/20	0.34

▸	PDK3	Q15120	1/20	0.34

▸	PDK4	Q16654	1/20	0.34

▸	MEN1	O00255	1/20	0.34

▸	KMT2A	Q03164	1/20	0.34

▸	PTPRC	P08575	1/20	0.33

▸	PTPN2	P17706	1/20	0.33

▸	PTPN1	P18031	1/20	0.33

▸	PTPRA	P18433	1/20	0.33

▸	PTPRB	P23467	1/20	0.33

▸	PTPRE	P23469	1/20	0.33

▸	PTPN6	P29350	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Lodoxamide SCHEMBL119881	0.88	GPR35 (1.00)	GPR35PTPRCPTPN2PTPN1PTPRA
Lodoxamide SCHEMBL24175	0.88	GPR35 (0.76)	GPR35PDK1PDK2PDK3PDK4
Lodoxamide SCHEMBL3141058	0.87	GPR35 (0.97)	GPR35PTPRCPTPN2PTPN1PTPRA
SCHEMBL11946654	0.84	GPR35 (0.90)	GPR35PTPRCPTPN2PTPN1PTPRA
SCHEMBL11703780	0.83	GPR35 (0.63)	GPR35PDK1PDK2PDK3PDK4
Lodoxamide SCHEMBL10897004	0.82	GPR35 (0.88)	GPR35PTPRCPTPN2PTPN1PTPRA
SCHEMBL11637849	0.81	GPR35 (0.76)	GPR35PTPN1PTPN6
Tromethamine SCHEMBL18190767	0.80	GPR35 (0.64)	GPR35PDK1PDK2PDK3PDK4
SCHEMBL11670458	0.80	GPR35 (0.50)	GPR35MEN1KMT2APTPRCPTPN2
SCHEMBL12803235	0.79	GPR35 (0.80)	GPR35PDK1PDK2PDK3PDK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-3993679-A	ANTIALLERGY	THE UPJOHN COMPANY (US)	1976-11-23	—	—	US	claimed