Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.47 |
| ▸ | CA9 | Q16790 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11867286 | 0.78 | CA12 (0.46) | CA12CA9CA1CA2MAPT | |
| SCHEMBL11872208 | 0.77 | LMNA (0.39) | KDM4EALDH1A1HPGDMAPTPOLB | |
| SCHEMBL11872017 | 0.75 | NPSR1 (0.44) | KDM4EALDH1A1HPGDMAPTPOLB | |
| SCHEMBL86336 | 0.74 | MAPT (0.50) | CA12CA9CA1CA2KDM4E | |
| SCHEMBL11570381 | 0.71 | AKR1B1 (0.56) | CA12CA9CA1CA2KDM4E | |
| SCHEMBL11871128 | 0.70 | AKR1B1 (0.55) | CA12CA9CA1CA2KDM4E | |
| SCHEMBL11814983 | 0.67 | L3MBTL1 (0.50) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL11481280 | 0.67 | MAPT (0.57) | KDM4EALDH1A1HPGDMAPTPOLB | |
| SCHEMBL11747371 | 0.67 | KDM4E (0.41) | KDM4E | |
| SCHEMBL10731756 | 0.66 | MAPT (0.46) | KDM4EALDH1A1MAPTPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3946036-A | 6,11-Dihydro-11-oxo-dibenzo[b,e]thiepine-2-acetic acids | SANDOZ LTD. (CH) | 1976-03-23 | — | — | US | disclosed |