Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4413021 | 0.80 | MAPT (0.44) | ALDH1A1MAPTMDM2SMN1; SMN2GAA | |
| SCHEMBL11182724 | 0.80 | — | — | |
| SCHEMBL7801786 | 0.78 | ALDH1A1 (0.45) | ALDH1A1MAPTMDM2SMN1; SMN2GAA | |
| SCHEMBL8663859 | 0.77 | MAPT (0.47) | ALDH1A1MAPTMDM2SMN1; SMN2GAA | |
| SCHEMBL11790343 | 0.76 | NPSR1 (0.35) | ALDH1A1MAPTGAANPSR1POLB | |
| SCHEMBL8803147 | 0.75 | MAPT (0.46) | ALDH1A1MAPTMDM2SMN1; SMN2GAA | |
| SCHEMBL3469591 | 0.74 | MAPT (0.49) | ALDH1A1MAPTMDM2SMN1; SMN2GAA | |
| SCHEMBL8594839 | 0.74 | ALDH1A1 (0.46) | ALDH1A1MAPTMDM2SMN1; SMN2GAA | |
| SCHEMBL4269080 | 0.74 | MAPT (0.49) | ALDH1A1MAPTMDM2SMN1; SMN2GAA | |
| SCHEMBL5455757 | 0.72 | NPSR1 (0.40) | ALDH1A1NPSR1HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3969520-A | 2-Amino-4[2-(1-lower alkyl-5-nitro-2-imidiazolyl)vinyl]pyrimidines for treating protozoal and bacterial infections | ISTITUTO CHEMIOTERAPICO ITALIANO S.P.A. (IT) | 1976-07-13 | — | — | US | disclosed |