Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dezocine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 13/20 | 1.00 |
| ▸ | OPRK1 known ✓ | P41145 | 6/20 | 0.63 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.63 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | MRGPRX2 | Q96LB1 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dezocine SCHEMBL29811203 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1OPRK1HSD11B1SIGMAR1 | |
| Dezocine SCHEMBL29682715 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1OPRK1HSD11B1SIGMAR1 | |
| Dezocine SCHEMBL12720257 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1OPRK1HSD11B1SIGMAR1 | |
| Dezocine SCHEMBL9685743 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1OPRK1HSD11B1SIGMAR1 | |
| Dezocine SCHEMBL11874182 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1OPRK1HSD11B1SIGMAR1 | |
| Dezocine SCHEMBL3072 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1OPRK1HSD11B1SIGMAR1 | |
| Dezocine SCHEMBL7781933 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1OPRK1HSD11B1SIGMAR1 | |
| Dezocine SCHEMBL1369581 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1OPRK1HSD11B1SIGMAR1 | |
| Dezocine SCHEMBL21081189 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1OPRK1HSD11B1SIGMAR1 | |
| Dezocine SCHEMBL25583319 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1OPRK1HSD11B1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3979434-A | ANALGESICS, ANTIINFLAMMATORY | AMERICAN HOME PRODUCTS CORPORATION (US) | 1976-09-07 | — | — | US | disclosed |