Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.40 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15091673 | 0.80 | TSHR (0.50) | IKBKBBRD4ADORA2AADORA1TSHR | |
| SCHEMBL29281802 | 0.79 | ADORA2A (0.46) | IKBKBBRD4ADORA2AADORA1TSHR | |
| SCHEMBL28308461 | 0.78 | ADORA2A (0.54) | IKBKBBRD4ADORA2AADORA1TSHR | |
| SCHEMBL6498979 | 0.76 | IKBKB (0.48) | IKBKBBRD4ADORA2AADORA1TSHR | |
| SCHEMBL18286700 | 0.76 | AKR1C3 (0.46) | IKBKBBRD4ADORA2AADORA1AKR1C3 | |
| SCHEMBL6011230 | 0.76 | TSHR (0.58) | IKBKBBRD4ADORA2AADORA1TSHR | |
| SCHEMBL29031730 | 0.76 | TSHR (0.48) | IKBKBBRD4ADORA2AADORA1TSHR | |
| SCHEMBL6570672 | 0.76 | TSHR (0.58) | IKBKBBRD4ADORA2AADORA1TSHR | |
| SCHEMBL398678 | 0.75 | ADORA2A (0.54) | IKBKBBRD4ADORA2AADORA1TSHR | |
| Hydrochloric Acid SCHEMBL6572095 | 0.74 | TSHR (0.56) | IKBKBBRD4ADORA2AADORA1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424866-A1 | SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS -SECRETASE INHIBITORS | High Point Pharmaceuticals, LLC (US) | 2012-03-07 | — | — | EP | disclosed |