Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.54 |
| ▸ | IKBKB | O14920 | 1/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | ATR | Q13535 | 1/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10835259 | 0.83 | ADORA2A (0.52) | ADORA2AADORA1IKBKBPIK3CDPIK3CA | |
| SCHEMBL3458331 | 0.81 | ADORA2A (0.52) | ADORA2AADORA1IKBKBPIK3CDPIK3CA | |
| SCHEMBL118742 | 0.78 | IKBKB (0.47) | ADORA2AADORA1IKBKBBRD4KDM1A | |
| SCHEMBL5327094 | 0.77 | ADORA1 (0.69) | ADORA2AADORA1IKBKBPIK3CDPIK3CA | |
| SCHEMBL1388662 | 0.77 | ADORA2A (0.72) | ADORA2AADORA1IKBKBPIK3CDPIK3CA | |
| SCHEMBL29655536 | 0.77 | ADORA2A (0.72) | ADORA2AADORA1IKBKBPIK3CDPIK3CA | |
| SCHEMBL28736470 | 0.76 | GRIN2B (0.48) | ADORA2AADORA1IKBKBPIK3CDPIK3CA | |
| Hydrochloric Acid SCHEMBL27752359 | 0.75 | ADORA2A (0.71) | ADORA2AADORA1IKBKBPIK3CDPIK3CA | |
| SCHEMBL3146889 | 0.75 | ADORA2A (0.52) | ADORA2AADORA1IKBKBPIK3CDPIK3CA | |
| SCHEMBL15411627 | 0.75 | IKBKB (0.54) | ADORA2AADORA1IKBKBPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114989164-A | Substituted 1H-imidazo [4,5-b ] pyridin-2 (3H) -ones and uses thereof | 詹森药业有限公司 | 2022-09-02 | — | — | CN | disclosed |
| CN-110062761-B | Substituted 1H-imidazo [4,5-b ] pyridin-2 (3H) -ones and uses thereof | 詹森药业有限公司 | 2022-05-13 | — | — | CN | disclosed |
| CN-110062761-A | Substituted 1H-imidazo [4,5-b ] pyridin-2 (3H) -ones and their use as GLUN2B receptor modulators | 詹森药业有限公司 | 2019-07-26 | — | — | CN | disclosed |