Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Betamethasone Benzoate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 18/20 | 0.77 |
| ▸ | PGR | P06401 | 4/20 | 0.77 |
| ▸ | MEN1 | O00255 | 1/20 | 0.77 |
| ▸ | USP2 | O75604 | 1/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.77 |
| ▸ | MMP1 | P03956 | 17/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Betamethasone Benzoate SCHEMBL49469 | 1.00 | NR3C1 (0.77) | NR3C1PGRMEN1USP2CYP3A4 | |
| Betamethasone Benzoate SCHEMBL11878006 | 1.00 | NR3C1 (0.77) | NR3C1PGRMEN1USP2CYP3A4 | |
| Betamethasone Benzoate SCHEMBL2954925 | 1.00 | NR3C1 (0.77) | NR3C1PGRMEN1USP2CYP3A4 | |
| Betamethasone Benzoate SCHEMBL21682645 | 0.98 | NR3C1 (0.77) | NR3C1PGRMEN1USP2CYP3A4 | |
| Betamethasone Benzoate SCHEMBL6898101 | 0.94 | NR3C1 (0.88) | NR3C1PGRMEN1USP2CYP3A4 | |
| SCHEMBL11585136 | 0.94 | NR3C1 (0.67) | NR3C1PGRMEN1USP2CYP3A4 | |
| SCHEMBL11582817 | 0.93 | NR3C1 (0.80) | NR3C1PGRMEN1USP2CYP3A4 | |
| SCHEMBL11582821 | 0.93 | NR3C1 (0.80) | NR3C1PGRMEN1USP2CYP3A4 | |
| SCHEMBL11849050 | 0.93 | NR3C1 (0.80) | NR3C1PGRMEN1USP2CYP3A4 | |
| Betamethasone Dipropionate SCHEMBL5489443 | 0.93 | NR3C1 (0.83) | NR3C1PGRMEN1USP2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3998701-A | Process for the preparation of 17-acyl esters of 17α, 21-dihydroxysteroids of the pregnane series and novel products | LARK S.P.A. (IT) | 1976-12-21 | — | — | US | disclosed |