Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | BACE1 | P56817 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | RB1 | P06400 | 3/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12380 | 0.90 | ACHE (0.48) | LTA4HHRH3SMN1; SMN2NPSR1ACHE | |
| SCHEMBL13573585 | 0.84 | LTA4H (0.56) | LTA4HHRH3POLBRAB9ATGFBR1 | |
| SCHEMBL30164338 | 0.84 | LTA4H (0.62) | LTA4HHRH3ACHEBACE1POLB | |
| SCHEMBL18290472 | 0.84 | LTA4H (0.62) | LTA4HHRH3ACHEBACE1POLB | |
| SCHEMBL18792185 | 0.84 | LTA4H (0.62) | LTA4HHRH3ACHEBACE1POLB | |
| SCHEMBL12449604 | 0.84 | LTA4H (0.53) | LTA4HHRH3POLBTGFBR1HDAC1 | |
| SCHEMBL20804106 | 0.83 | ACHE (0.49) | HRH3SMN1; SMN2NPSR1ACHEBACE1 | |
| SCHEMBL11434269 | 0.81 | HRH3 (0.69) | HRH3SMN1; SMN2ACHEBACE1POLB | |
| SCHEMBL14848246 | 0.80 | ACHE (0.54) | HRH3SMN1; SMN2NPSR1ACHEBACE1 | |
| SCHEMBL5864236 | 0.80 | HRH3 (0.72) | HRH3SMN1; SMN2ACHEBACE1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499146-B1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2016-09-21 | — | — | EP | disclosed |
| WO-2011058149-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-05-19 | — | — | WO | disclosed |