Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 9/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.62 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.60 |
| ▸ | PGR | P06401 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.60 |
| ▸ | AR | P10275 | 3/20 | 0.60 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.55 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.55 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | SHBG | P04278 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2019946 | 0.94 | HIF1A (0.61) | HIF1ALMNACYP17A1NR3C1PGR | |
| SCHEMBL27780950 | 0.93 | CYP17A1 (0.72) | HIF1ALMNACYP17A1NR3C1PGR | |
| SCHEMBL28106323 | 0.93 | CYP17A1 (0.72) | HIF1ALMNACYP17A1NR3C1PGR | |
| SCHEMBL2020622 | 0.90 | HIF1A (0.73) | HIF1ALMNANR3C1PGRSMN1; SMN2 | |
| SCHEMBL13768969 | 0.90 | HIF1A (0.64) | HIF1ALMNACYP17A1NR3C1PGR | |
| SCHEMBL16017612 | 0.90 | HIF1A (0.63) | HIF1ALMNACYP17A1NR3C1PGR | |
| SCHEMBL21706395 | 0.90 | HIF1A (0.63) | HIF1ALMNACYP17A1NR3C1PGR | |
| Algestone Acetonide SCHEMBL42582 | 0.85 | CYP17A1 (0.85) | HIF1ALMNACYP17A1NR3C1PGR | |
| SCHEMBL11878820 | 0.83 | HIF1A (0.56) | HIF1ALMNANR3C1PGRSMN1; SMN2 | |
| SCHEMBL11865778 | 0.82 | HIF1A (0.54) | HIF1ALMNANR3C1PGRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3956316-A | PROGESTATIONAL AND SALT-RETAINING AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1976-05-11 | — | — | US | disclosed |