Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 9/20 | 0.73 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.73 |
| ▸ | PGR | P06401 | 5/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.73 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.73 |
| ▸ | AR | P10275 | 1/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.73 |
| ▸ | NR3C2 | P08235 | 6/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | SHBG | P04278 | 2/20 | 0.64 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13768969 | 0.93 | HIF1A (0.64) | HIF1ANR3C1PGRCYP3A4SMN1; SMN2 | |
| SCHEMBL16017612 | 0.92 | HIF1A (0.63) | HIF1ANR3C1PGRCYP3A4SMN1; SMN2 | |
| SCHEMBL21706395 | 0.92 | HIF1A (0.63) | HIF1ANR3C1PGRCYP3A4SMN1; SMN2 | |
| SCHEMBL2019946 | 0.92 | HIF1A (0.61) | HIF1ANR3C1PGRCYP3A4SMN1; SMN2 | |
| SCHEMBL11880147 | 0.90 | HIF1A (0.62) | HIF1ANR3C1PGRCYP3A4SMN1; SMN2 | |
| Desonide SCHEMBL17503255 | 0.87 | NR3C1 (0.76) | HIF1ANR3C1PGRCYP3A4SMN1; SMN2 | |
| SCHEMBL13654495 | 0.87 | HIF1A (0.63) | HIF1ANR3C1PGRCYP3A4SMN1; SMN2 | |
| SCHEMBL11878820 | 0.86 | HIF1A (0.56) | HIF1ANR3C1PGRCYP3A4SMN1; SMN2 | |
| Flurandrenolide SCHEMBL5042122 | 0.85 | CYP3A4 (1.00) | HIF1ANR3C1PGRCYP3A4SMN1; SMN2 | |
| Flurandrenolide SCHEMBL13769220 | 0.85 | CYP3A4 (1.00) | HIF1ANR3C1PGRCYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110160167-A1 | Steroid Derivatives Acting As Glucocorticosteroid Receptor Agonists | ASTRAZENECA AB (SE) | 2011-06-30 | — | — | US | disclosed |
| US-20110160167-A1 | Steroid Derivatives Acting As Glucocorticosteroid Receptor Agonists | ASTRAZENECA AB (SE) | 2011-06-30 | — | — | US | disclosed |
| US-4839282-A | Preparation of 3-oxo-Δ1,4 -steroids | SCHERING AKTIENGESELLSCHAFT (DE) | 1989-06-13 | — | — | US | disclosed |
| US-3975378-A | ANTIINFLAMMATORY | SYNTEX (U.S.A.) INC. (US) | 1976-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160167-A1 | Steroid Derivatives Acting As Glucocorticosteroid Receptor Agonists | NR3C1, NR3C2, MC2R | HIF1A 3437/4885NR3C1 1/4885PGR 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.