Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GBA1 | P04062 | 1/20 | 0.47 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11888859 | 0.86 | KMT2A (0.65) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL11889043 | 0.82 | PKM (0.52) | KMT2AMEN1ALDH1A1L3MBTL1PKM | |
| SCHEMBL11888958 | 0.81 | FAAH (0.53) | KMT2AHTTCYP2D6GAA | |
| SCHEMBL11889042 | 0.80 | CYP2D6 (0.49) | KMT2AMEN1ALDH1A1L3MBTL1CYP2D6 | |
| SCHEMBL11888911 | 0.80 | HDAC3 (0.50) | KMT2ADCTPP1CYP2D6SMN1; SMN2 | |
| SCHEMBL31684031 | 0.78 | KMT2A (0.87) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL24754516 | 0.77 | KMT2A (0.68) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL29783799 | 0.77 | KMT2A (0.68) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL1146846 | 0.77 | KMT2A (0.50) | KMT2AMEN1MAPTL3MBTL1PKM | |
| SCHEMBL27596864 | 0.77 | KMT2A (0.84) | KMT2AMEN1ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102471265-B | Piperidine derivatives and their use for the treatment of obesity, diabetes, dyslipidemia and atherosclerosis | HOFFMANN LA ROCHE | 2014-09-03 | — | — | CN | claimed |
| EP-2480532-B1 | PIPERIDINE DERIVATIVES AND THEIR USE TO TREAT OBESITY, DIABETES, DYSLIPIDEMIA AND ATHEROSCLEROSIS | HOFFMANN LA ROCHE (CH) | 2013-11-20 | — | — | EP | claimed |
| US-8399676-B2 | Piperidine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2013-03-19 | — | — | US | claimed |
| EP-2480532-A1 | PIPERIDINE DERIVATIVES AND THEIR USE TO TREAT OBESITY, DIABETES, DYSLIPIDEMIA AND ATHEROSCLEROSIS | F. Hoffmann-La Roche AG (CH) | 2012-08-01 | — | — | EP | claimed |
| CN-102471265-A | Piperidine derivatives and their use for the treatment of obesity, diabetes, dyslipidemia and atherosclerosis | HOFFMANN LA ROCHE | 2012-05-23 | — | — | CN | claimed |
| CN-102471265-B | Piperidine derivatives and their use for the treatment of obesity, diabetes, dyslipidemia and atherosclerosis | HOFFMANN LA ROCHE | 2014-09-03 | — | — | CN | disclosed |
| EP-2480532-B1 | PIPERIDINE DERIVATIVES AND THEIR USE TO TREAT OBESITY, DIABETES, DYSLIPIDEMIA AND ATHEROSCLEROSIS | HOFFMANN LA ROCHE (CH) | 2013-11-20 | — | — | EP | disclosed |
| US-8399676-B2 | Piperidine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2013-03-19 | — | — | US | disclosed |
| EP-2480532-A1 | PIPERIDINE DERIVATIVES AND THEIR USE TO TREAT OBESITY, DIABETES, DYSLIPIDEMIA AND ATHEROSCLEROSIS | F. Hoffmann-La Roche AG (CH) | 2012-08-01 | — | — | EP | disclosed |
| CN-102471265-A | Piperidine derivatives and their use for the treatment of obesity, diabetes, dyslipidemia and atherosclerosis | HOFFMANN LA ROCHE | 2012-05-23 | — | — | CN | disclosed |