Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | NAMPT | P43490 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11889773 | 0.93 | MAPT (0.54) | NPC1MAPTLMNAPOLBGAA | |
| SCHEMBL11889725 | 0.85 | MAPT (0.56) | NPC1MAPTLMNAPOLBGAA | |
| SCHEMBL11889855 | 0.84 | KMT2A (0.53) | NPC1MAPTLMNAPOLBGAA | |
| SCHEMBL11889599 | 0.83 | F13A1 (0.53) | NPC1MAPTLMNAPOLBGAA | |
| SCHEMBL11889801 | 0.82 | MAPT (0.74) | NPC1MAPTLMNAPOLBGAA | |
| SCHEMBL11889586 | 0.81 | MAPT (0.58) | NPC1MAPTLMNAGAAKDM4E | |
| SCHEMBL12306055 | 0.81 | RAB9A (0.63) | NPC1MAPTLMNAGAAKDM4E | |
| SCHEMBL11889651 | 0.80 | MAPT (0.65) | NPC1MAPTLMNAGAAKDM4E | |
| SCHEMBL11889802 | 0.78 | MAPT (0.57) | NPC1MAPTLMNAGAAKDM4E | |
| SCHEMBL2459317 | 0.78 | MAPT (0.57) | NPC1MAPTLMNAPOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101035777-B | HCV replication modulators | ANGELETTI P IST RICHERCHE BIO | 2013-01-02 | — | — | CN | disclosed |
| EP-1799663-B1 | Modulators of HCV replication | ANGELETTI P IST RICHERCHE BIO (IT) | 2012-08-01 | — | — | EP | disclosed |
| CN-101035777-A | HCV replication modulators | ANGELETTI P IST RICHERCHE BIO (IT) | 2007-09-12 | — | — | CN | disclosed |