Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.41 |
| ▸ | LSS | P48449 | 2/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3092378 | 1.00 | MAPT (0.41) | MAPTMEN1CYP3A4ALOX15KMT2A | |
| SCHEMBL12042841 | 0.89 | TRPV1 (0.33) | MAPTCYP3A4LSSTRPV1 | |
| SCHEMBL1443819 | 0.87 | BTN3A1 (0.33) | CYP3A4 | |
| SCHEMBL14576007 | 0.87 | BTN3A1 (0.33) | CYP3A4 | |
| SCHEMBL11890235 | 0.84 | ALDH1A1 (0.47) | ALOX15ALDH1A1TRPV1 | |
| SCHEMBL17997139 | 0.84 | SMYD2 (0.36) | MAPTMEN1CYP3A4ALOX15KMT2A | |
| SCHEMBL14616409 | 0.84 | BTN3A1 (0.33) | CYP3A4 | |
| SCHEMBL1443774 | 0.83 | BTN3A1 (0.32) | MAPT | |
| SCHEMBL14576030 | 0.83 | BTN3A1 (0.32) | MAPT | |
| SCHEMBL25203066 | 0.82 | TRPV1 (0.38) | ALOX15LSSTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8629268-B2 | Cyclisation process of forming a multiple ring compound | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2014-01-14 | — | — | US | disclosed |
| US-20130046090-A1 | CYCLISATION PROCESS OF FORMING A MULTIPLE RING COMPOUND | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2013-02-21 | — | — | US | disclosed |
| US-8227645-B2 | Cyclisation process of forming a multiple ring compound | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2012-07-24 | — | — | US | disclosed |
| US-20110319481-A1 | SCHWEINFURTHIN ANALOGUES | Government of the United States of America, National Institute of Health (US) | 2011-12-29 | — | — | US | disclosed |
| US-7902228-B2 | such as: 3-Deoxyschweinfurthin B; anticancer assay; e.g. breast cancer or a cancer of the CNS or renal system diagnosis | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2011-03-08 | — | — | US | disclosed |
| US-20100228058-A1 | CYCLISATION PROCESS OF FORMING A MULTIPLE RING COMPOUND | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2010-09-09 | — | — | US | disclosed |
| US-20080227852-A1 | SCHWEINFURTHIN ANALOGUES | THE GOVERNMENT OF THE UNITED STATES OF AMERICA | 2008-09-18 | — | — | US | disclosed |
| US-7358377-B2 | such as: 3-Deoxyschweinfurthin B; tested and were found to have anti-cancer by NCI 60-cell line anticancer assay; e.g. breast cancer or a cancer of the CNS or renal system | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2008-04-15 | — | — | US | disclosed |
| US-20080015232-A1 | SCHWEINFURTHIN ANALOGUES | US GOVERNMENT - SECRETARY FOR THE ARMY | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100228058-A1 | CYCLISATION PROCESS OF FORMING A MULTIPLE RING COMPOUND | DHPS, GGPS1, COASY | MAPT 4010/4885MEN1 458/4885CYP3A4 45/4885 |
| US-20080015232-A1 | SCHWEINFURTHIN ANALOGUES | ERH, HRAS, HNRNPH1 | MAPT 3664/4885MEN1 782/4885CYP3A4 2116/4885 |
| US-20130046090-A1 | CYCLISATION PROCESS OF FORMING A MULTIPLE RING COMPOUND | COASY, AKR1C4, AKR1C2 | MAPT 3702/4885MEN1 541/4885CYP3A4 92/4885 |
| US-20080227852-A1 | SCHWEINFURTHIN ANALOGUES | ERH, HRAS, HNRNPH1 | MAPT 3664/4885MEN1 782/4885CYP3A4 2116/4885 |
| US-20110319481-A1 | SCHWEINFURTHIN ANALOGUES | ERH, HRAS, HNRNPH1 | MAPT 3664/4885MEN1 782/4885CYP3A4 2116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.