Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.45 |
| ▸ | POLB | P06746 | 9/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 9/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | ESR1 | P03372 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | RECQL | P46063 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.45 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | UBE2I | P63279 | 10/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11894413 | 1.00 | KDM4E (0.45) | KDM4EPOLBTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL11894885 | 0.75 | KDM4E (0.56) | KDM4EPOLBTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL11894636 | 0.74 | KDM4E (0.53) | KDM4EPOLBTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL11894507 | 0.73 | POLB (0.50) | KDM4EPOLBTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL11895160 | 0.70 | KDM4E (0.44) | KDM4EPOLBTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL11894860 | 0.70 | EIF4A1 (0.53) | KDM4EPOLBTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL2266020 | 0.68 | ALDH1A1 (0.58) | KDM4EPOLBL3MBTL1ALDH1A1HPGD | |
| SCHEMBL2266018 | 0.68 | ALDH1A1 (0.58) | KDM4EPOLBL3MBTL1ALDH1A1HPGD | |
| SCHEMBL17147462 | 0.67 | ALDH1A1 (0.59) | KDM4EPOLBTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL17137841 | 0.67 | ALDH1A1 (0.82) | KDM4EPOLBTDP1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2487175-A1 | PHARMACEUTICAL PRODUCT CONTAINING AROMATIC HETEROCYCLIC COMPOUND | Kyowa Hakko Kirin Co., Ltd. (JP) | 2012-08-15 | — | — | EP | disclosed |
| US-20120196854-A1 | PHARMACEUTICAL COMPOSITION COMPRISING AROMATIC HETEROCYCLIC COMPOUND | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2012-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120196854-A1 | PHARMACEUTICAL COMPOSITION COMPRISING AROMATIC HETEROCYCLIC COMPOUND | CYP2C18, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CYP2B6 | KDM4E 2321/4885POLB 2858/4885TDP1 3847/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.