SCHEMBL11899641

SCHEMBL11899641

COc1ncnc2c1ncn2[C@H](C)[C@H](CCc1ccccc1)O[Si](C)(C)C(C)(C)C

nearest known ligand 0.50

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
FLT4 P35916 1/20 0.41
KDR P35968 1/20 0.41
HPGD P15428 1/20 0.41
TAAR1 Q96RJ0 1/20 0.39
CCNB2 O95067 2/20 0.39
CDK1 P06493 2/20 0.39
CCNB1 P14635 2/20 0.39
CCNB3 Q8WWL7 2/20 0.39
CDK2 P24941 1/20 0.39
DAPK1 P53355 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11899822 1.00 FLT4 (0.41) FLT4KDRHPGDTAAR1CCNB2
SCHEMBL1740457 0.87 ADORA2A (0.47)
SCHEMBL1741649 0.87 CCNB2 (0.39) CCNB2CDK1CCNB1CCNB3CDK2
SCHEMBL11900412 0.87 CCNB2 (0.39) CCNB2CDK1CCNB1CCNB3CDK2
SCHEMBL1740463 0.87 ADORA2A (0.47)
SCHEMBL11899223 0.86 FLT4 (0.41) FLT4KDRHPGDTAAR1
SCHEMBL11899434 0.82 PDE2A (0.44) TAAR1CCNB2CDK1CCNB1CCNB3
SCHEMBL11899824 0.82 PDE2A (0.44) TAAR1CCNB2CDK1CCNB1CCNB3
Hydrochloric Acid SCHEMBL1741396 0.81 FLT4 (0.49) FLT4KDRHPGDTAAR1CCNB2
SCHEMBL1742938 0.81 FLT4 (0.49) FLT4KDRHPGDTAAR1CCNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120202287-A1 Stem Cell Culture Methods ITI SCOTLAND LIMITED (GB) 2012-08-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120202287-A1 Stem Cell Culture Methods KIT, SOX18, MCL1 FLT4 3150/4885KDR 3274/4885HPGD 837/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.