Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.71 |
| ▸ | RUNX1 | Q01196 | 6/20 | 0.57 |
| ▸ | CBFB | Q13951 | 3/20 | 0.57 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.54 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11903467 | 0.90 | TRPV1 (0.57) | TRPV1RUNX1CBFBCHEK2SCN10A | |
| SCHEMBL11903468 | 0.86 | TRPV1 (0.74) | TRPV1RUNX1CBFBCHEK2NPC1 | |
| SCHEMBL11903652 | 0.85 | TRPV1 (0.77) | TRPV1RUNX1CBFBCHEK2NPC1 | |
| SCHEMBL11903447 | 0.85 | TRPV1 (0.73) | TRPV1RUNX1CBFBCHEK2NPC1 | |
| SCHEMBL11903498 | 0.85 | TRPV1 (0.77) | TRPV1RUNX1CBFBCHEK2NPC1 | |
| SCHEMBL11903481 | 0.85 | TRPV1 (0.72) | TRPV1RUNX1CBFBCHEK2NPC1 | |
| SCHEMBL11903519 | 0.85 | TRPV1 (0.72) | TRPV1RUNX1CBFBCHEK2SCN10A | |
| SCHEMBL11903648 | 0.80 | TRPV1 (0.69) | TRPV1RUNX1CBFBCHEK2NPC1 | |
| SCHEMBL31027956 | 0.79 | NPC1 (0.66) | NPC1ALDH1A1TP53HPGDSMN1; SMN2 | |
| SCHEMBL21705120 | 0.79 | NPC1 (0.66) | NPC1ALDH1A1TP53HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293780-B1 | Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making | U.S. DEPARTMENT OF ENERGY (US) | 2012-10-23 | — | — | US | disclosed |
| US-8242284-B1 | Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF ENERGY (US) | 2012-08-14 | — | — | US | disclosed |