Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.74 |
| ▸ | CBFB | Q13951 | 2/20 | 0.60 |
| ▸ | RUNX1 | Q01196 | 5/20 | 0.60 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.57 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.54 |
| ▸ | BACE1 | P56817 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TCF4 | P15884 | 1/20 | 0.52 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11903464 | 0.89 | TRPV1 (0.60) | TRPV1CBFBRUNX1CHEK2NR4A2 | |
| SCHEMBL11903447 | 0.88 | TRPV1 (0.73) | TRPV1CBFBRUNX1CHEK2NPC1 | |
| SCHEMBL11903652 | 0.88 | TRPV1 (0.77) | TRPV1CBFBRUNX1CHEK2NPC1 | |
| SCHEMBL11903498 | 0.88 | TRPV1 (0.77) | TRPV1CBFBRUNX1CHEK2NPC1 | |
| SCHEMBL11903481 | 0.87 | TRPV1 (0.72) | TRPV1CBFBRUNX1CHEK2NPC1 | |
| SCHEMBL11903474 | 0.86 | TRPV1 (0.71) | TRPV1CBFBRUNX1CHEK2NPC1 | |
| SCHEMBL11903519 | 0.84 | TRPV1 (0.72) | TRPV1CBFBRUNX1CHEK2NPC1 | |
| SCHEMBL11903648 | 0.82 | TRPV1 (0.69) | TRPV1CBFBRUNX1CHEK2NPC1 | |
| SCHEMBL24074352 | 0.82 | TRPV1 (0.61) | TRPV1CBFBRUNX1CHEK2NPC1 | |
| SCHEMBL16121415 | 0.81 | TRPV1 (0.63) | TRPV1CBFBRUNX1CHEK2BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293780-B1 | Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making | U.S. DEPARTMENT OF ENERGY (US) | 2012-10-23 | — | — | US | disclosed |
| US-8242284-B1 | Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF ENERGY (US) | 2012-08-14 | — | — | US | disclosed |